Bubble Manipulation by Self Organization of Bubbles inside Ultrasonic Wave
Bubble Manipulation by Self Organization of Bubbles inside Ultrasonic Wave
复制标题
DOI：
10.1143/jjap.44.4583
复制
发表时间：
2005-06
影响因子：
1.5
通讯作者：
Y. Yamakoshi;Masato Koganezawa
中科院分区：
文献类型：
--
作者：
Y. Yamakoshi;Masato Koganezawa
超声微泡技术在未来医学和生物技术领域具有广阔的应用前景。例如，人们认为使用超声波的气泡捕获可能在药物或基因传递系统中发挥重要作用，以便在病变组织中捕获药物或基因。通常，当气泡被设计成携带有效载荷时，比如药物或基因，它们往往比自由气泡更坚硬。这些硬气泡受到很小的声辐射力，这不足以对气泡进行操纵。本文提出了一种利用超声波操纵微泡的新方法。该方法利用种子气泡来操纵目标气泡。当种子气泡被引入超声波场时，它们开始振荡，产生一定大小的气泡聚集。然后引入目标气泡，目标气泡附着在种子气泡周围，形成具有双层结构的气泡团（内层：种子气泡，外层：目标气泡）。目标气泡被操纵成一个双层气泡团。利用聚氯乙烯（PVC）壳泡进行了基础实验。当只引入目标气泡时，不会捕获目标气泡。然而，如果提前引入种子气泡，它们就会被困住。
Microbubble manipulation using ultrasonic waves is a promising technology in the fields of future medicine and biotechnology. For example, it is considered that bubble trapping using ultrasonic waves may play an important role in drug or gene delivery systems in order to trap the drugs or genes in the diseased tissue. Usually, when bubbles are designed so that they carry payloads, such as drug or gene, they tend to be harder than free bubbles. These hard bubbles receive a small acoustic radiation force, which is not sufficient for bubble manipulation. In this paper, a novel method of microbubble manipulation using ultrasonic waves is proposed. This method uses seed bubbles in order to manipulate target bubbles. When the seed bubbles are introduced into the ultrasonic wave field, they start to oscillate to produce a bubble aggregation of a certain size. Then the target bubbles are introduced, the target bubbles attach around the seed bubbles producing a bubble mass with bilayers (inner layer: seed bubbles, outer layer: target bubbles). The target bubbles are manipulated as a bilayered bubble mass. Basic experiments are carried out using polyvinyl chloride (PVC) shell bubbles. No target bubbles are trapped when only the target bubbles are introduced. However, they are trapped if the seed bubbles are introduced in advance.