Obesity and migraine - A population study
Obesity and migraine - A population study
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DOI：
10.1212/01.wnl.0000197218.05284.82
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发表时间：
2006-02-28
期刊：
影响因子：
9.9
通讯作者：
Lipton, RB
中科院分区：
文献类型：
--
作者：
Bigal, ME;Liberman, JN;Lipton, RB
目的：探讨体重指数(BMI)对偏头痛患病率、发作频率和临床特征的影响。方法：在一项基于人群的电话采访研究中，作者收集了有关头痛、身高和体重的信息。根据体重指数，30,215名参与者被分为五类：1，体重不足(=35)。偏头痛患病率和模拟的头痛特征被评估为BMI的函数，并通过协变量(年龄、性别、婚姻状况、收入、医疗、抑郁)进行调整。结果：受试者主要为女性(65%为女性)和中年(平均年龄38.4岁)。BMI组与偏头痛的患病率无关，但与头痛发作的频率有关。在正常体重组中，4.4%的人每月头痛10~15天，增加到超重的5.8%(优势比[OR]=1.3)、肥胖的13.6%(OR=2.9)和病态肥胖的20.7%(OR=5.7)。重度头痛的受试者的比例随着BMI的增加而增加，病态肥胖者的比例是正常体重者的两倍(OR=1.9)。BMI类别中的残疾、畏光和畏音也表现出类似的显著相关性。结论：虽然偏头痛的患病率与体重指数无关，但偏头痛的发作频率、严重程度和临床特征随着体重指数的增加而增加。
Objective: To assess the influence of body mass index (BMI) on the prevalence, attack frequency, and clinical features of migraine. Methods: In a population-based telephone interview study, the authors gathered information on headache, height, and weight. The 30,215 participants were divided into five categories, based on BMI: 1, underweight (= 35). Migraine prevalence and modeled headache features were assessed as a function of BMI, adjusting by covariates (age, sex, marital status, income, medical treatment, depression). Results: Subjects were predominantly female (65% female) and in middle life (mean age 38.4). BMI group was not associated with the prevalence of migraine, but was associated with the frequency of headache attacks. In the normal weight group, 4.4% had 10 to 15 headache days per month, increasing to 5.8% of the overweight (odds ratio [OR] = 1.3), 13.6% of the obese (OR = 2.9), and 20.7% of the morbidly obese (OR = 5.7). The proportion of subjects with severe headache pain increased with BMI, doubling in the morbidly obese relative to the normally weighted (OR = 1.9). Similar significant associations were demonstrated with BMI category for disability, photophobia, and phonophobia. Conclusion: Though migraine prevalence is not associated with body mass index, attack frequency, severity, and clinical features of migraine increase with body mass index group.