Kinetic pinning and biological antifreezes
Kinetic pinning and biological antifreezes
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DOI：
10.1103/physrevlett.93.128102
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发表时间：
2004-09-17
影响因子：
8.6
通讯作者：
Tkachenko, AV
中科院分区：
文献类型：
--
作者：
Sander, LM;Tkachenko, AV
生物防冻剂可保护冷水生物免遭冻结。一个例子是抗冻蛋白（AFP），它附着在冰晶表面并阻止生长。迄今为止，尚未以定量方式了解生长停滞的机制。我们提出了基于动力学模型的完整理论。我们使用“枕头上的石头”图片。我们的冰点抑制随 AFP 浓度变化的理论在定量上是准确的。它正确描述了冰点抑制对蛋白质几何形状的依赖性，并可能导致合成 AFP 设计的进步。
Biological antifreezes protect cold-water organisms from freezing. An example is the antifreeze proteins (AFP's) that attach to the surface of ice crystals and arrest growth. The mechanism for growth arrest has not been heretofore understood in a quantitative way. We present a complete theory based on a kinetic model. We use the "stones on a pillow" picture. Our theory of the suppression of the freezing point as a function of the concentration of the AFP is quantitatively accurate. It gives a correct description of the dependence of the freezing point suppression on the geometry of the protein, and might lead to advances in design of synthetic AFP's.