Treatment outcome of oral appliance in patients with REM-related obstructive sleep apnea.
Treatment outcome of oral appliance in patients with REM-related obstructive sleep apnea.
复制标题
与REM相关的阻塞性睡眠呼吸暂停患者口服器械的治疗结果。
DOI：
10.1007/s11325-019-01966-5
复制
发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Shiomi T
中科院分区：
文献类型：
--
作者：
Nishio Y;Hoshino T;Murotani K;Furuhashi A;Baku M;Sasanabe R;Kazaoka Y;Shiomi T
口腔矫治器（OA）用于治疗阻塞性睡眠呼吸暂停（OSA）患者。本研究的目的是评估OA治疗快速眼动（REM）相关OSA患者的疗效。46例REM相关OSA患者和107例非阶段特异性OSA患者在多导睡眠图（PSG）诊断后接受OA治疗，并进行PSG随访睡眠测试。根据以下治疗成功标准评估疗效和治疗结果预测因子：#1，与基线相比，呼吸暂停低通气指数（AHI）降低至小于5且> 50%; #2，与基线相比，AHI降低至小于10且> 50%;以及#3，与基线相比，AHI降低> 50%。根据标准#1、#2和#3，REM相关OSA的成功率分别为45.7%、50.0%和50.0%，非阶段特异性OSA的成功率分别为36.4%、52.3%和63.6%。两组成功率无显著差异。在以每个标准作为反应变量的多变量logistic回归分析中，只有BMI被提取为显著的预测因子。根据这三个标准，基于最大约登指数定义的BMI临界值分别为26.2 kg/m2、25.6 kg/m2和26.2 kg/m2。REM相关OSA和非阶段特异性OSA的治疗成功率无显著差异。在REM相关OSA患者中，BMI对OA的治疗结果影响更大。
Oral appliances (OA) are used to treat patients with obstructive sleep apnea (OSA). The purpose of this study is to evaluate the efficacy of OA treatment in patients with rapid eye movement (REM)–related OSA. Forty-six patients with REM-related OSA and 107 with non-stage-specific OSA were prescribed OA treatment after diagnosis by polysomnography (PSG) and a follow-up sleep test by PSG was conducted. Efficacy and treatment outcome predictors were evaluated according to the following criteria for treatment success: #1, reduction of the apnea-hypopnea index (AHI) to less than 5 and > 50% compared with baseline; #2, AHI reduction to less than 10 and > 50% compared with baseline; and #3, > 50% AHI reduction compared with baseline. Success rates according to criteria #1, #2, and #3 were 45.7%, 50.0%, and 50.0% in REM-related OSA and 36.4%, 52.3%, and 63.6% in non-stage-specific OSA, respectively. No significant differences in success rate were found between the two groups. In multivariate logistic regression analysis with each criterion as the response variable, only BMI was extracted as a significant predictor. The BMI cutoff values defined based on the maximum Youden index according to the three criteria were 26.2 kg/m2, 25.6 kg/m2, and 26.2 kg/m2, respectively. No significant differences in success rate of OA treatment were found between REM-related OSA and non-stage-specific OSA. BMI has greater impact on treatment outcome of OA in patients with REM-related OSA.
登录
查看更多内容
影响因子：
1.2
作者：
Hoshino, Tetsuro;Sasanabe, Ryujiro;Shiomi, Toshiaki
通讯作者：
Shiomi, Toshiaki
影响因子：
2.5
作者：
Conwell, Walter;Patel, Bhakti;Mokhlesi, Babak
通讯作者：
Mokhlesi, Babak
影响因子：
2.9
作者：
Furuhashi, A.;Yamada, S.;Kazaoka, Y.
通讯作者：
Kazaoka, Y.
影响因子：
9.6
作者：
Tsuiki, Satoru;Ito, Eiki;Inoue, Yuichi
通讯作者：
Inoue, Yuichi
影响因子：
4.3
作者：
Ramar, Kannan;Dort, Leslie C.;Chervin, Ronald D.
通讯作者：
Chervin, Ronald D.