Tumor size and lymph node status in multifocal breast cancer
Tumor size and lymph node status in multifocal breast cancer
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DOI：
10.1111/j.1524-4741.2006.00365.x
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发表时间：
2007-01-01
期刊：
影响因子：
2.1
通讯作者：
Fabregas, Rafael
中科院分区：
文献类型：
--
作者：
Tresserra, Francisco;Rodriguez, Ignacio;Fabregas, Rafael
肿瘤大小与乳腺癌的淋巴转移有关。在多灶性病变中，是否考虑每个肿瘤的最大直径的总和存在争议。对122例多灶性乳腺癌患者和177例单灶性乳腺癌患者进行了回顾性研究，比较了肿瘤大小与淋巴结转移的关系。在多灶性肿瘤中，考虑了两种大小：最大肿瘤的直径和所有病变的综合直径。使用年龄、病变数量、组织类型和分级等变量，通过三种不同的Logistic模型建立关系。在单灶性或多灶性病变的最大直径与多灶性病变的联合直径相同的情况下，后者显示较少的淋巴结转移，表明联合直径高估了病变的大小。我们的结果表明，在多灶性乳腺癌中，只有最大的肿块乳腺癌的直径与淋巴结转移有关。
Tumor size correlates with lymph node metastasis in breast cancer. In multifocal lesions there is controversy about considering the summation of the largest diameter of each tumor. A total of 122 patients with multifocal breast cancer were compared in a retrospective study with 177 patients with unifocal tumors, correlating tumor size with lymph node metastasis. In multifocal tumors, two sizes were considered: the diameter of the largest tumor and the combined diameter of all lesions. Relationship was established by three different logistic models using variables such as age, number of lesions, histologic type, and grade. At a same size of the largest diameter of a unifocal or multifocal lesions and the combined diameter of a multifocal lesion, the latter shows less probability of nodal metastasis indicating that combined diameter is an overestimation of the lesion size. Our results indicate that in multifocal breast cancer, only the diameter of the largest tumor breast cancer has relationship with lymph node metastasis.