Cell-mediated immunity to Histoplasma capsulatum.
Cell-mediated immunity to Histoplasma capsulatum.
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对荚膜组织胞浆菌的细胞介导的免疫。
DOI：
10.1053/srin.2001.24240
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Newman,SL
中科院分区：
文献类型：
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作者：
Newman,SL
荚膜组织胞浆菌是一种兼性胞内病原体，也是最常见的系统性真菌感染的病原体。在过去的几年里，关于这种微生物的生物学、生物化学和分子遗传学有了许多新的见解。本文综述了宿主防御囊状芽孢杆菌酵母菌的免疫学研究进展，重点介绍了细胞免疫的发展，以及该真菌在巨噬细胞内生存和繁殖所采用的策略。
Histoplasma capsulatum is a facultative intracellular pathogen, and the causative agent of the most common systemic fungal infection. Over the past several years, many new insights have been learned concerning the biology, biochemistry, and molecular genetics of this microorganism. This review focuses on the immunology of host defense against H. capsulatum yeasts with emphasis on the development of cell-mediated immunity, and the strategies used by the fungus to survive and multiply within macrophages.