Oxidative Stress
Oxidative Stress
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DOI：
10.1177/0148607111434963
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发表时间：
2012-03-01
影响因子：
3.4
通讯作者：
Preiser, Jean-Charles
中科院分区：
文献类型：
--
作者：
Preiser, Jean-Charles
氧化应激的定义是活性氧（ROS）水平的增加和抗氧化机制的低活性之间的不平衡。增加的氧化应激可诱导对细胞结构的损伤并潜在地破坏组织。然而，ROS是足够的细胞功能所必需的，包括线粒体产生能量。增加的氧化应激已经在生理条件下，如老化和运动，并在几种病理条件下，包括癌症，神经退行性疾病，心血管疾病，糖尿病，炎症性疾病和中毒。然而，抗氧化剂的预防大多是无效的。因此，在明确定义的条件下进行严格的科学评估是强制性的，以确定在人类医学中操纵氧化途径的适当位置。(JPEN肠外肠内营养杂志2012;36：147-154）
Oxidative stress is defined by an imbalance between increased levels of reactive oxygen species (ROS) and a low activity of antioxidant mechanisms. An increased oxidative stress can induce damage to the cellular structure and potentially destroy tissues. However, ROS are needed for adequate cell function, including the production of energy by the mitochondria. Increased oxidative stress has been incriminated in physiological conditions, such as aging and exercise, and in several pathological conditions, including cancer, neurodegenerative diseases, cardiovascular diseases, diabetes, inflammatory diseases, and intoxications. However, prevention by antioxidants has been mostly inefficient. Therefore, a rigorous scientific evaluation in well-defined conditions is mandatory to define the appropriate place for manipulations of the oxidative pathways in human medicine. (JPEN J Parenter Enteral Nutr. 2012;36: 147-154)