Fat and water 1H MRI to investigate effects of leptin in obese mice.
Fat and water 1H MRI to investigate effects of leptin in obese mice.
复制标题
脂肪和水 1H MRI 研究瘦素对肥胖小鼠的影响。
DOI：
10.1038/oby.2009.133
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Bansal,Navin
中科院分区：
文献类型：
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作者：
James,JudyR;Hertel,JeAnneL;Babsky,AndriyM;Hekmatyar,SK;Heiman,MarkL;Jackson,CharlesV;Bansal,Navin
已知瘦素与体重和脂肪含量的调节有关。采用1H磁共振成像（1H MRI）技术研究外源性瘦素对瘦素缺乏肥胖小鼠腹腔内脏（VS）和皮下（SC）脂肪体积及肝脏脂水比的影响。在给药前1天和给药7天（0.3 mg/kg/天）后，获得对照组和瘦素给药组小鼠的化学位移选择性脂肪和水1H MRI。肝脏脂水比和VS脂肪体积随给药显著降低，而SC脂肪体积无变化。使用MRI对身体不同部位的脂肪和水含量进行无创测量，将有助于评估治疗肥胖和其他代谢紊乱的新药。
Leptin is known to be associated with regulation of body weight and fat content. The effects of exogenous leptin on abdominal visceral (VS) and subcutaneous (SC) fat volume and hepatic fat‐to‐water ratio in leptin‐deficient obese mice were investigated by1H magnetic resonance imaging (MRI). Chemical shift‐selected fat and water1H MRI of control and leptin‐treated mice were obtained 1 day before treatment and after 7 days of treatment (0.3 mg/kg/day). Hepatic fat‐to‐water ratio and VS fat volume decreased significantly with treatment, whereas SC fat volume did not change. Noninvasive measurement of fat and water content in different body regions using MRI should prove useful for evaluating new drugs for the treatment of obesity and other metabolic disorders.