Predictors of positive axillary lymph nodes after sentinel lymph node biopsy in breast cancer
Predictors of positive axillary lymph nodes after sentinel lymph node biopsy in breast cancer
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DOI：
10.1016/s0002-9610(01)00719-x
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发表时间：
2001-10-01
影响因子：
3
通讯作者：
Burak, WE
中科院分区：
文献类型：
--
作者：
Abdessalam, SF;Zervos, EE;Burak, WE
目的：本研究的目的是确定当非前哨淋巴结（SLN）呈阳性时预测非前哨淋巴结（SLN）转移的因素。方法：分析前瞻性数据库，其中包括1997年7月至2000年8月期间因浸润性乳腺癌接受SLN活检的患者（n = 442）。100例（22.6%）患者有一个或多个阳性前哨淋巴结，并进行分析，以确定因素，预测额外的积极腋nodes.Results：100例阳性前哨淋巴结，40例（40%）有额外的转移在非前哨淋巴结。预测非SLN转移的唯一显著变量是肿瘤淋巴管浸润（P = 0.004）、淋巴结扩展（P < 0.001）和SLN内转移灶的大小增加（P = 0.011）。在分析那些只有淋巴管浸润，淋巴结延伸，SLN转移> 2mm，92%的患者被发现有额外的阳性nodes.Conclusions：在浸润性乳腺癌和前哨淋巴结阳性的患者中，淋巴管浸润，淋巴结延伸，和转移的大小增加都显着增加额外的阳性nodes.Conclusions的频率。(C)2001 Excerpta Medica，Inc. All rights reserved.
Objective: The purpose of this study was to determine the factors that predict the presence of metastasis in nonsentinel lymph nodes (SLN) when the SLN is positive.Methods: A prospective database was analyzed and included patients who underwent SLN biopsy for invasive breast cancer from July 1997 to August 2000 (n = 442). One hundred (22.6%) patients had one or more positive SLNs, and were analyzed to determine factors that predicted additional positive axillary nodes.Results: Of the 100 patients with a positive SLN, 40 patients (40%) had additional metastasis in non-SLNs. The only significant variables that predicted non-SLN metastasis were tumor lymphovascular invasion (P = 0.004), extranodal extension (P < 0.001), and increasing size of the metastasis within the SLN (P = 0.011). In analyzing just those patients who had lymphovascular invasion, extranodal extension, and a SLN metastasis > 2mm, 92% were found to have additional positive nodes.Conclusions: In patients with invasive breast cancer and a positive sentinel lymph node, lymphovascular invasion, extranodal extension, and increasing size of the metastasis all significantly increase the frequency of additional positive nodes. (C) 2001 Excerpta Medica, Inc. All rights reserved.