Young, non-Hispanic Black men and women exhibit divergent peripheral and cerebral vascular reactivity.
Young, non-Hispanic Black men and women exhibit divergent peripheral and cerebral vascular reactivity.
复制标题
年轻，非西班牙裔黑人男女表现出不同的外围和脑血管反应性。
DOI：
10.1113/ep090168
复制
发表时间：
2022-05
影响因子：
2.7
通讯作者：
Brothers RM
中科院分区：
文献类型：
--
作者：
Akins JD;Martin ZT;Patik JC;Curtis BM;Campbell JC;Olvera G;Brothers RM
在美国，相对于其他种族/族裔群体，非西班牙裔黑人 (BL) 人群的心脑血管疾病仍然更为突出。通常，这些疾病的表现会出现性别差异，尽管这些差异可能不会在 BL 人群中完全体现。虽然涉及多种机制，但血管功能的差异可能有所贡献。研究表明，与非西班牙裔白人相比，黑人的几个血管区域的血管舒张作用减弱，尽管这项工作的大部分内容没有评估性别差异。因此，本研究旨在确定年轻 BL 女性 (BW) 和男性 (BM) 的血管功能指数是否不同。 11 名 BW 和 15 名 BM（22 (4) 岁 vs. 23 (3) 岁）参与了本研究。每个参与者都接受了肱动脉血流介导的扩张（FMD）、闭塞后反应性充血（RH）以及再呼吸引起的高碳酸血症期间脑血管舒缩反应性的测试。 BW 比 BM 表现出更大的调整后 FMD（所有 P < 0.05），但在评估血流速度（所有 P > 0.39）或血流反应性（所有 P < 0.05）时，相对湿度相似或更低。在一系列高碳酸血症范围内，BW 的大脑中动脉血流速度和脑血管电导指数均高于 BM（两者 P < 0.001）。这些初步数据表明，年轻的 BW 相对于年轻的 BM 具有更好的血管功能，尽管不同指标之间的情况不一致。这些发现让我们深入了解 BM 和 BW 之间不同的流行病学发现。需要进一步的研究来阐明可能的机制并将这些生理反应与流行病学观察联系起来。
In the U.S., cardiovascular and cerebrovascular diseases remain more prominent in the non-Hispanic Black (BL) population relative to other racial/ethnic groups. Typically, sex differences emerge in the manifestation of these diseases, though these differences may not fully materialize in the BL population. While numerous mechanisms are implicated, differences in vascular function likely contribute. Research has demonstrated blunted vasodilation in several vascular regions in BL versus non-Hispanic White individuals, though much of this work did not assess sex differences. Therefore, this study aimed to ascertain if indices of vascular function are different between young, BL women (BW) and men (BM). Eleven BW and 15 BM (22 (4) vs. 23 (3) y) participated in this study. Each participant underwent testing for brachial artery flow-mediated dilation (FMD), post-occlusive reactive hyperemia (RH), and cerebral vasomotor reactivity during rebreathing-induced hypercapnia. BW exhibited greater adjusted FMD than BM (P < 0.05 for all), but similar or lower RH when assessed as blood velocity (P > 0.39 for all) or blood flow reactivity (P < 0.05 for all), respectively. Across a range of hypercapnia, BW had greater middle cerebral artery blood velocity and cerebrovascular conductance index than BM (P < 0.001 for both). These preliminary data suggest that young, BW have greater vascular function relative to young, BM, though this was inconsistent across different indices. These findings provide insight into the divergent epidemiological findings between BM and BW. Further research is needed to elucidate possible mechanisms and relate these physiological responses to epidemiological observations.