Simvastatin Induces Neuroprotection in 6‐OHDA‐Lesioned PC12 via the PI3K/AKT/Caspase 3 Pathway and Anti‐Inflammatory Responses
Simvastatin Induces Neuroprotection in 6‐OHDA‐Lesioned PC12 via the PI3K/AKT/Caspase 3 Pathway and Anti‐Inflammatory Responses
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DOI：
10.1111/cns.12053
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发表时间：
2013-03
影响因子：
5.5
通讯作者：
Yunqi Xu;L. Long;Junqiang Yan;Lei Wei;Mengqiu Pan;Huimin Gao;P. Zhou;Mei Liu;Can Zhu
中科院分区：
文献类型：
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作者：
Yunqi Xu;L. Long;Junqiang Yan;Lei Wei;Mengqiu Pan;Huimin Gao;P. Zhou;Mei Liu;Can Zhu
除了降低胆固醇的原始应用外，他汀类药物还显示出多种神经保护作用。炎症反应和PI 3 K/AKT/caspase 3通路与帕金森病（PD）多巴胺能神经元死亡密切相关。本研究旨在探讨辛伐他汀如何通过调节PI 3 K/AKT/caspase 3和调节炎症介质对6-羟基多巴胺损伤的PC 12的影响。
In addition to their original applications for lowering cholesterol, statins display multiple neuroprotective effects. Inflammatory reactions and the PI3K/AKT/caspase 3 pathway are strongly implicated in dopaminergic neuronal death in Parkinson's disease (PD). This study aims to investigate how simvastatin affects 6‐hydroxydopamine‐lesioned PC12 via regulating PI3K/AKT/caspase 3 and modulating inflammatory mediators.