Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders
Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders
复制标题
DOI：
10.1016/j.bbi.2019.01.026
复制
发表时间：
2019-07-01
影响因子：
15.1
通讯作者：
Ullum, Henrik
中科院分区：
文献类型：
--
作者：
Burgdorf, Kristoffer Solvsten;Trabjerg, Betina B.;Ullum, Henrik
背景资料：常见的传染性病原体已与精神疾病，自我暴力和冒险的behaviors.Methods：这种病例对照研究审查登记数据81,912个人从丹麦献血者的研究，以确定个人谁有精神病诊断（N = 2591），有企图或自杀（N = 655），或有交通事故（N = 2724）。对所有病例，对照组按年龄和性别进行频率匹配，共11,546例参与者。在25.9%的人群中检测到弓形虫，并与精神分裂症相关（比值比[OR]，1.47; 95%置信区间[CI]，1-03-2.09）。考虑到时间性，病原体暴露先于结果，相关性甚至更强（IRR，2.78; 95% CI，1-27-6-09）。交通事故与弓形虫病的关联性很弱（OR，141; 95%CI，1-00-1.23，p = 0.054）。在60.8%的研究人群中检测到CMV，并与任何精神疾病相关（OR，147; 95%CI，1.06-1-29），但也有一小部分神经症、应激相关和躯体形式障碍（OR，1.27; 95%CI，1.12-1-44），和企图或自杀（OR，1.31; 95%CI，1.10-1-56）。考虑到时间性，任何精神疾病（IRR，1.37; 95% CI，1.08-174）和心境障碍（IRR，1.43; 95% CI，1.01-2-04）均与CMV暴露相关。交通事故与CMV感染无相关性（OR为1.06; 95%CI为0.97-1-17）。结论：本研究首次对交通事故与CMV感染的时间性进行了研究，为交通事故与CMV感染的因果关系提供了证据。弓形虫和精神分裂症，巨细胞病毒和任何精神疾病之间。
Background: Common infectious pathogens have been associated with psychiatric disorders, self-violence and risk-taking behavior.Methods: This case-control study reviews register data on 81,912 individuals from the Danish Blood Donor Study to identify individuals who have a psychiatric diagnosis (N = 2591), have attempted or committed suicide (N = 655), or have had traffic accidents (N = 2724). For all cases, controls were frequency matched by age and sex, resulting in 11,546 participants.Plasma samples were analyzed for immunoglobulin G (IgG) antibodies against Toxoplasma gondii and cytomegalovirus (CMV).Results: T. gondii was detected in 25.9% of the population and was associated with schizophrenia (odds ratio [OR], 1.47; 95% confidence interval [CI], 1-03-2.09). Accounting for temporality, with pathogen exposure preceding outcome, the association was even stronger (IRR, 2.78; 95% CI, 1-27-6-09). A very weak association between traffic accident and toxoplasmosis (OR, 141; 95% CI, 1-00-1.23, p = 0.054) was found.CMV was detected in 60.8% of the studied population and was associated with any psychiatric disorder (OR, 147; 95% CI, 1.06-1-29), but also with a smaller group of neurotic, stress-related, and somatoform disorders (OR, 1.27; 95% CI, 1.12-1-44), and with attempting or committing suicide (OR, 1.31; 95% CI, 1.10-1-56). Accounting for temporality, any psychiatric disorder (IRR, 1.37; 95% CI, 1.08-174) and mood disorders (IRR, 1.43; 95% CI, 1.01-2-04) were associated with exposure to CMV. No association between traffic accident and CMV (OR, 1.06; 95% CI, 0.97-1-17) was found.Conclusions: This large-scale serological study is the first study to examine temporality of pathogen exposure and to provide evidence of a causal relationship between T. gondii and schizophrenia, and between CMV and any psychiatric disorder.