Postmenopausal circulating levels of 2- and 16ýý-hydroxyestrone and risk of endometrial cancer.
Postmenopausal circulating levels of 2- and 16ýý-hydroxyestrone and risk of endometrial cancer.
复制标题
绝经后 2- 和 16α-羟基雌酮的循环水平与子宫内膜癌的风险。
DOI：
10.1038/bjc.2011.381
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发表时间：
2011
影响因子：
8.8
通讯作者：
Lundin,E
中科院分区：
文献类型：
--
作者：
Zeleniuch-Jacquotte,A;Shore,RE;Afanasyeva,Y;Lukanova,A;Sieri,S;Koenig,KL;Idahl,A;Krogh,V;Liu,M;Ohlson,N;Muti,P;Arslan,AA;Lenner,P;Berrino,F;Hallmans,G;Toniolo,P;Lundin,E
背景：有研究表明雌激素代谢途径的相对重要性可能影响包括子宫内膜癌在内的雌激素依赖性肿瘤的风险。一种假设是2-羟基途径是保护性的，而16α-羟基途径是harmful.Methods：我们进行了一项病例对照研究嵌套在三个前瞻性队列，以评估是否循环2-羟基雌酮：16α-羟基雌酮（2-OHE 1：16α-OHE 1）的比例与绝经后妇女子宫内膜癌的风险呈负相关。共纳入179例病例和336例对照，这些病例在队列、年龄和献血日期上匹配。结果：子宫内膜癌风险随着两种代谢物水平的增加而增加，在校正子宫内膜癌风险因素的分析中，2-OHE 1和16α-OHE 1的优势比分别为2.4（95%CI = 1.3，4.6; P趋势= 0.007）和1.9（95%CI = 1.1，3.5; P趋势= 0.03）。进一步调整雌酮或雌二醇水平后，这些相关性减弱，不再具有统计学意义。2-OHE 1：16α-OHE 1比值与子宫内膜癌的发生无显著相关性。结论：我们的研究结果不支持雌激素通过2-OH途径的代谢比通过16α-OH途径的代谢更高的假说，即雌激素通过2-OH途径的代谢比通过16α-OH途径的代谢更高的假说具有保护作用。
Background:It has been suggested that the relative importance of oestrogen-metabolising pathways may affect the risk of oestrogen-dependent tumours including endometrial cancer. One hypothesis is that the 2-hydroxy pathway is protective, whereas the 16α-hydroxy pathway is harmful.Methods:We conducted a case–control study nested within three prospective cohorts to assess whether the circulating 2-hydroxyestrone: 16α-hydroxyestrone (2-OHE1: 16α-OHE1) ratio is inversely associated with endometrial cancer risk in postmenopausal women. A total of 179 cases and 336 controls, matching cases on cohort, age and date of blood donation, were included. Levels of 2-OHE1 and 16α-OHE1 were measured using a monoclonal antibody-based enzyme assay.Results:Endometrial cancer risk increased with increasing levels of both metabolites, with odds ratios in the top tertiles of 2.4 (95% CI= 1.3, 4.6; P trend= 0.007) for 2-OHE1 and 1.9 (95% CI= 1.1, 3.5; P trend= 0.03) for 16α-OHE1 in analyses adjusting for endometrial cancer risk factors. These associations were attenuated and no longer statistically significant after further adjustment for oestrone or oestradiol levels. No significant association was observed for the 2-OHE1: 16α-OHE1 ratio.Conclusion:Our results do not support the hypothesis that greater metabolism of oestrogen via the 2-OH pathway, relative to the 16α-OH pathway, protects against endometrial cancer.