Response to Dietary Oxalate after Bariatric Surgery
Response to Dietary Oxalate after Bariatric Surgery
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DOI：
10.2215/cjn.02560312
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发表时间：
2012-12-01
影响因子：
9.8
通讯作者：
Heilberg, Ita Pfeferrnan
中科院分区：
文献类型：
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作者：
Froeder, Leila;Arasaki, Carlos Haruo;Heilberg, Ita Pfeferrnan
背景和目的减肥手术（BS）可能与草酸盐排泄增加和肾结石风险增高有关。本研究旨在调查泌尿异常和对急性草酸负荷的反应，作为对该人群中草酸肠道吸收的间接评估。设计、设置、参与者和测量从61例BS后（中位98个月）患者和30例病态肥胖（MO）参与者中收集24小时尿液标本；膳食信息通过24小时食品召回获得。对21名MO和22名BS后12个月的患者进行了口服草酸负荷试验（OLT），包括在禁食2小时后和摄入375 mg草酸（菠菜汁）2、4和6小时后的尿液样本。10例bs后患者在手术前也接受了OLT （bs前）。结果尿量过低的比例(
Background and objectives Bariatric surgery (BS) may be associated with increased oxalate excretion and a higher risk of nephrolithiasis. This study aimed to investigate urinary abnormalities and responses to an acute oxalate load as an indirect assessment of the intestinal absorption of oxalate in this population.Design, setting, participants, & measurements Twenty-four hour urine specimens were collected from 61 patients a median of 98 months after BS (post-BS) as well as from 30 morbidly obese (MO) participants; dietary information was obtained through 24-hour food recalls. An oral oxalate load test (OLT), consisting of 2-hour urine samples after overnight fasting and 2, 4, and 6 hours after consuming 375 mg of oxalate (spinach juice), was performed on 21 MO and 22 post-BS patients 12 months after BS. Ten post-BS patients also underwent OLT before surgery (pre-BS).Results There was a higher percentage of low urinary volume (