Long-term outcomes of amniotic membrane treatment in acute Stevens-Johnson syndrome/toxic epidermal necrolysis.
Long-term outcomes of amniotic membrane treatment in acute Stevens-Johnson syndrome/toxic epidermal necrolysis.
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DOI：
10.1016/j.jtos.2020.03.004
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发表时间：
2020-07
期刊：
影响因子：
--
通讯作者：
Saeed HN
中科院分区：
文献类型：
--
作者：
Shanbhag SS;Hall L;Chodosh J;Saeed HN
报告以移植（AMT）和自留羊膜（ProKera®装置，PD）形式使用羊膜（AM）治疗急性史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症（SJS/TEN）的长期结果。对 2008 年 1 月至 2018 年 1 月期间在马萨诸塞州眼耳医院诊断为 SJS/TEN 的所有患者的电子记录进行了审查。选择在急性 SJS/TEN 中接受 AM 的患者。仅纳入出院后随访≥3个月的患者。分析了 29 名患者 55 只眼睛的数据。所有 55 只眼睛在皮疹出现后平均间隔 5 天（四分位距 (IQR)：3-7 天）接受第一次 AM。 56% 的眼睛 (31/55) 接受了 AMT，而 44% (24/55) 的眼睛接受了 PD。百分之四十 (22/55) 的眼睛需要重复 AMT 或 PD。初次 AM 后的中位随访时间为 2.5 年（IQR：1.2-3.6 年）。最后一次随访时，87% 的眼睛 (48/55) 的最佳矫正视力≥ 20/40。慢性期最常见的并发症是睑板腺疾病和干眼症，分别见于 78% (43/55) 和 58% (32/55) 的眼睛。长期结果表明，在 SJS/TEN 急性期早期使用 AM 可能可以有效缓解 SJS/TEN 后的严重视力丧失。然而，即使使用 AM，与眼睑相关的并发症和干眼症仍然是一个常见问题。
To report the long-term outcomes of amniotic membrane (AM) use in the form of transplantation (AMT) and self-retained amniotic membrane (ProKera® device, PD) in acute Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Electronic records of all patients with a diagnosis of SJS/TEN at Massachusetts Eye and Ear between January 2008 and January 2018 were reviewed. Patients who received AM in acute SJS/TEN were selected. Only patients with follow-up ≥ 3 months after discharge were included. Data of 55 eyes of 29 patients were analyzed. All 55 eyes received the first AM at a median interval of 5 days (inter-quartile range (IQR): 3–7 days) after onset of skin rash. Fifty-six percent of eyes (31/55) received AMT while 44% (24/55) received PD. Forty percent of eyes (22/55) required a repeat AMT or PD. Median follow-up after initial AM was 2.5 years (IQR: 1.2–3.6 years). At last follow-up, the best-corrected visual acuity was ≥ 20/40 in 87% of eyes (48/55). The most common complications in the chronic phase were meibomian gland disease and dry eye, seen in 78% of eyes (43/55) and 58% of eyes (32/55) respectively. Long-term results show that early use of AM in the acute phase of SJS/TEN may be effective in mitigating severe vision loss after SJS/TEN. However, eyelid-related complications and dry eye remain a common problem even with the use of AM.
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影响因子：
4.2
作者：
Butt, Tehreem F.;Cox, Anthony R.;Ferner, Robin E.
通讯作者：
Ferner, Robin E.
影响因子：
6.4
作者：
Shanbhag, Swapna S.;Chodosh, James;Saeed, Hajirah N.
通讯作者：
Saeed, Hajirah N.
影响因子：
2.8
作者：
Shay, Elizabeth;Khadem, John J.;Tseng, Scheffer C. G.
通讯作者：
Tseng, Scheffer C. G.
DOI：
10.2147/opth.s45054
发表时间：
2013
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Ciralsky JB;Sippel KC
通讯作者：
Sippel KC
影响因子：
4.2
作者：
Basu, Sayan;Shanbhag, Swapna S.;Sangwan, Virender S.
通讯作者：
Sangwan, Virender S.