ALTERATIONS IN THE HEMAGGLUTININ ASSOCIATED WITH ADAPTATION OF INFLUENZA-B VIRUS TO GROWTH IN EGGS
ALTERATIONS IN THE HEMAGGLUTININ ASSOCIATED WITH ADAPTATION OF INFLUENZA-B VIRUS TO GROWTH IN EGGS
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DOI：
10.1016/0042-6822(85)90105-9
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发表时间：
1985-01-01
期刊：
影响因子：
3.7
通讯作者：
SCHILD, GC
中科院分区：
文献类型：
--
作者：
ROBERTSON, JS;NAEVE, CW;SCHILD, GC
现在确定了与适应鸡蛋中生长相关的B型流感病毒血凝素（HA）的分子变化。仅在哺乳动物细胞培养物中生长的流感B病毒HA远端的特异性糖基化位点在卵适应过程中丢失或改变。由于HA的功能是将病毒吸附到细胞上，因此可以得出结论，在该位置去除或修饰寡糖结构是B型流感病毒附着并感染卵的尿囊细胞所必需的，并且这对分子的抗原构型具有重要意义。
The molecular changes in the hemagglutinin (HA) of influenza B virus associated with adaptation to growth in eggs were now identified. A specific glycosylation site at the distal tip of the HA of influenza B virus grown exclusively in mammalian cell culture is lost or altered during egg adaptation. Since the HA functions in adsorption of virus to cells, it is concluded that removal or modification of an oligosaccharide structure at this position is required for influenza B virus to attach to and infect the allantois cells of the egg and that this has important implications for the antigenic configuration of the molecule.