Clinical applications of metabolomics in oncology: a review.
Clinical applications of metabolomics in oncology: a review.
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DOI：
10.1158/1078-0432.ccr-08-1059
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发表时间：
2009-01-15
期刊：
影响因子：
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通讯作者：
Eckhardt SG
中科院分区：
文献类型：
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作者：
Spratlin JL;Serkova NJ;Eckhardt SG
代谢组学是系统生物学中的一门组学科学，是对生物系统中内源性代谢产物的全面定量评价。无论是单独或分组为代谢组学谱，代谢物的检测是在细胞，组织或生物流体中进行的核磁共振光谱或质谱。代谢组在肿瘤学中有多种用途，包括癌症的早期检测和诊断，以及作为药物作用的预测和药效学标志物。尽管如此，肿瘤学界对代谢组学缺乏了解，对其方法学过程、技术挑战和临床应用感到困惑。代谢组学，当用作转化研究工具时，可以提供实验室和临床之间的联系，特别是因为代谢和分子成像技术，如正电子发射断层扫描和磁共振光谱成像，能够在体内无创地区分代谢标志物。在这里，我们回顾了代谢组学的当前和潜在的应用，重点是它作为癌症诊断，预后和治疗评估的生物标志物的使用。
Metabolomics, an omic science in systems biology, is the global quantitative assessment of endogenous metabolites within a biological system. Either individually or grouped as a metabolomic profile, detection of metabolites is carried out in cells, tissues, or biofluids by either nuclear magnetic resonance spectroscopy or mass spectrometry. There is potential for the metabolome to have a multitude of uses in oncology, including the early detection and diagnosis of cancer and as both a predictive and pharmacodynamic marker of drug effect. Despite this, there is lack of knowledge in the oncology community regarding metabolomics and confusion about its methodologic processes, technical challenges, and clinical applications. Metabolomics, when used as a translational research tool, can provide a link between the laboratory and clinic, particularly because metabolic and molecular imaging technologies, such as positron emission tomography and magnetic resonance spectroscopic imaging, enable the discrimination of metabolic markers noninvasively in vivo. Here, we review the current and potential applications of metabolomics, focusing on its use as a biomarker for cancer diagnosis, prognosis, and therapeutic evaluation.