Impact of oral statin therapy on clinical outcomes in patients with cT1 breast cancer.
Impact of oral statin therapy on clinical outcomes in patients with cT1 breast cancer.
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DOI：
10.1186/s12885-023-10631-w
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发表时间：
2023-03-09
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影响因子：
3.8
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中科院分区：
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之前一项研究他汀类药物使用与乳腺癌之间关系的荟萃分析报告称，他汀类药物对乳腺癌的抑制作用在早期病例中可能更为明显。在这项研究中，我们的目的是调查乳腺癌诊断时高脂血症治疗的效果，并检查其与原发灶为2厘米或更小、通过前哨淋巴结活检或腋窝淋巴结清扫进行病理学评估的所谓cT1乳腺癌患者中腋窝淋巴结转移的相关性。我们还研究了降脂药物对早期乳腺癌患者预后的影响。在排除不符合标准的病例后，我们分析了 719 例被诊断为乳腺癌、术前影像学检查发现原发灶在 2 厘米以下且接受手术但未进行术前化疗的患者的数据。关于高脂血症药物，虽然发现亲脂性他汀类药物的使用与淋巴结转移之间存在相关性(p = 0.042)，但未发现他汀类药物的使用与淋巴结转移之间存在相关性(p = 0.226)。此外，治疗高脂血症（p = 0.047，风险比：0.399）和服用他汀类药物（p = 0.028，风险比：0.328）后，无病生存期延长。在 cT1 乳腺癌中，结果表明口服他汀类药物治疗可能有助于取得良好的结果。在线版本包含可在 10.1186/s12885-023-10631-w 获取的补充材料。
A previous meta-analysis examining the relationship between statin use and breast cancer reported that the inhibitory effect of statins on breast cancer may be more pronounced in early-stage cases. In this study, we aimed to investigate the effects of hyperlipidemia treatment at the time of breast cancer diagnosis and to examine its correlation with metastasis to axillary lymph nodes among patients with so-called cT1 breast cancer whose primary lesion was 2 cm or less and was pathologically evaluated by sentinel lymph node biopsy or axillary lymph node dissection. We also investigated the effects of hyperlipidemic drugs on the prognosis of patients with early-stage breast cancer. After excluding cases that did not meet the criteria, we analyzed data from 719 patients who were diagnosed with breast cancer, with a primary lesion of 2 cm or less identified by preoperative imaging, and who underwent surgery without preoperative chemotherapy. Regarding hyperlipidemia drugs, no correlation was found between statin use and lymph node metastasis (p = 0.226), although a correlation was found between lipophilic statin use and lymph node metastasis (p = 0.042). Also, the disease-free survival periods were prolonged following treatment of hyperlipidemia (p = 0.047, hazard ratio: 0.399) and statin administration (p = 0.028, hazard ratio: 0.328). In cT1 breast cancer, the results suggest that oral statin therapy may contribute to favorable outcomes. The online version contains supplementary material available at 10.1186/s12885-023-10631-w.
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