An Efficient Hydration and Tandem Transfer Hydrogenation of Alkynes for the Synthesis of Alcohol in Water
An Efficient Hydration and Tandem Transfer Hydrogenation of Alkynes for the Synthesis of Alcohol in Water
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DOI：
10.1055/s-0040-1707233
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发表时间：
2020-08
期刊：
影响因子：
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通讯作者：
Nianhua Luo;Yuhong Zhong;Jitian Liu;Ouyang Lu;Renshi Luo
中科院分区：
文献类型：
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作者：
Nianhua Luo;Yuhong Zhong;Jitian Liu;Ouyang Lu;Renshi Luo
摘要：本文介绍了一种在温和条件下，甲酸促进水合和金属-配体双功能铱催化转移加氢串联制备醇类化合物的方法。该转化简单、高效，可以用多种炔烃进行，收率高，立体选择性好。实验结果表明，催化活性高，TOF可达25000次。重要的是，这种转化可以在水中进行，因此是绿色和环保的。
Abstract A practical and efficient method for the synthesis of alcohols in one pot from readily available alkynes via a tandem process by formic acid promoted hydration and metal-ligand bifunctional iridium-catalyzed transfer hydrogenation under mild conditions has been described. This transformation is simple, efficient, and can be performed with a variety of alkynes in good yields and with excellent stereoselectivities. Experimental results showed high catalytic activity, and turnover frequency (TOF) up to 25000. Importantly, this transformation can be conducted in water, and is thus green and environmentally friendly.