Serum mesothelin has a higher diagnostic utility than hyaluronic acid in malignant mesothelioma
Serum mesothelin has a higher diagnostic utility than hyaluronic acid in malignant mesothelioma
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DOI：
10.1016/j.clinbiochem.2009.03.007
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发表时间：
2009-07-01
影响因子：
2.8
通讯作者：
Scherpereel, Arnaud
中科院分区：
文献类型：
--
作者：
Grigoriu, Bogdan;Chahine, Bachar;Scherpereel, Arnaud
材料与方法：对76例恶性胸膜间皮瘤（MPM）患者和33例胸膜转移癌患者的血清和胸液进行了透明质酸（HA）和可溶性间皮素（sMesothelin，sMET）的检测，并对两种可能的恶性胸膜间皮瘤（MPM）的诊断价值进行了比较（Mets组）和27例石棉暴露相关良性胸腔积液（BPLAE）患者。使用100 μ g/L的血清HA截止值，Mets组中有8/33例患者（24.2%）为阳性，而MPM组中有20/76例患者（26.3%）为阳性，BPLAE组中只有1/27例患者为阳性。MPM与Mets或BPLAE组血清HA的ROC曲线下面积仅为0.617，而间皮素的ROC曲线下面积为0.755。结论：血清间皮素对MPM的诊断敏感性高于透明质酸，两者联合应用无明显意义。(c)2009年加拿大临床化学家协会。爱思唯尔公司出版All rights reserved.
We assessed comparatively the diagnostic value of two potential malignant pleural mesothelioma (MPM) markers: hyaluronic acid (HA) and soluble mesothelin.Materials and method: We measured serum and pleural fluid values of mesothelin and hyaluronic acid in 76 patients with MPM, 33 patients with pleural metastases of carcinomas (Mets group) and 27 patients with benign pleural effusion related to asbestos exposure (BPLAE).Results: Using a serum HA cut-off of 100 mu g/L, 8 patients/33 (24.2%) were positive in the Mets group versus 20/76 (26.3%) in the MPM group and only 1/27 BPLAE patients. The area under ROC curve for serum HA in MPM versus Mets or BPLAE groups was only 0.617 while it was 0.755 for mesothelin. In pleural fluid, both markers had similar diagnostic values.Conclusions: Serum mesothelin is more sensitive than hyaluronic acid in diagnosing MPM and there is no benefit in combining both markers. (c) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.