Lens regeneration in mice: implications in cataracts
Lens regeneration in mice: implications in cataracts
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DOI：
10.1016/j.exer.2003.10.021
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发表时间：
2004-02-01
影响因子：
3.4
通讯作者：
Tsonis, PA
中科院分区：
文献类型：
--
作者：
Call, MK;Grogg, MW;Tsonis, PA
当晶状体切除术后留下透镜囊时，成年小鼠的透镜再生是可能的。透镜由剩余的粘附的透镜上皮细胞再生，其在数天内分化形成透镜纤维，显示正常形态和弓形区域。上皮细胞向间充质细胞的转化也见于早期阶段。因此，小鼠可以成为白内障研究、手术和治疗不可缺少的动物模型。(C)2003 Elsevier Ltd.保留所有权利。
Lens regeneration in adult mice is possible when the lens capsule is left behind after lentectomy. The lens is regenerated by the remaining adherent lens epithelial cells, which differentiate to form lens fibres within days, showing normal morphology and bow regions. Epithelial to mesenchymal cell transformation is also seen during the early stages. The mouse, therefore, can become an indispensable animal model for cataract research, surgery and therapy. (C) 2003 Elsevier Ltd. All rights reserved.