Toward an objective characterization of an anhedonic phenotype: A signal detection approach
Toward an objective characterization of an anhedonic phenotype: A signal detection approach
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DOI：
10.1016/j.biopsych.2004.11.026
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发表时间：
2005-02-15
影响因子：
10.6
通讯作者：
O'Shea, JP
中科院分区：
文献类型：
--
作者：
Pizzagalli, DA;Jahn, AL;O'Shea, JP
背景：在定义和表征表型方面的困难阻碍了精神遗传学和临床神经科学的进展。减少的方法相关的行为和anbedonia（缺乏对快乐的反应）被认为是抑郁症的主要特征，但很少有研究使用实验室为基础的措施，以客观地表征这些construction.Methods：为了评估享乐能力与抑郁症，特别是快感缺乏，症状，62名参与者完成了信号检测任务的基础上的差分强化时间表。结果：两个正确反应之间的奖励频率不相等产生了反应偏差（即，识别与更频繁的奖励配对的刺激的系统偏好）。抑郁症状升高的受试者（贝克抑郁量表评分大于或等于16）未能显示出反应偏倚。受损的奖励反应预测较高的快感缺失症状1个月后，控制一般的负面activity.Conclusions：受损的倾向，以调节行为的功能，事先加强可能强调减少享乐能力抑郁症。当应用于临床人群时，对参与者调节行为的倾向作为奖励的函数的客观评估可能为改善抑郁症的表型定义提供有力的工具，从而为抑郁症的神经科学研究提供可靠的行为筛查方法。
Background: Difficulties in defining and characterizing phenotypes has hindered progress in psychiatric genetics and clinical neuroscience. Decreased approach-related behavior and anbedonia (lack of responsiveness to pleasure) are considered cardinal features of depression, but few studies have used laboratory-based measures to objectively characterize these constructs.Methods: To assess hedonic capacity in relation to depressive, particularly anhedonic, symptoms, 62 participants completed a signal-detection task based on a differential reinforcement schedule. Anhedonia was operationalized as decreased reward responsiveness.Results: Unequal frequency of reward between two correct responses produced a response bias (i.e., a systematic preference to identify the stimulus paired with the more frequent reward). Subjects with elevated depressive symptoms (Beck Depression Inventory scores greater than or equal to 16) failed to show a response bias. Impaired reward responsiveness predicted higher anhedonic symptoms 1 month later, after controlling for general negative activity.Conclusions: Impaired tendency to modulate behavior as a function of prior reinforcement might underline diminished hedonic capacity in depression. When applied to a clinical population, objective assessments of participants' propensity to modulate behavior as a function of reward might provide a powerful tool for improving the phenotypic definition of depression and thus offer a reliable behavioral screening approach for neuroscience studies of depression.