A Mild and Versatile Method for the Synthesis of Alkyl Ethers from MOM Ethers and Application to the Preparation of Sterically Crowded Ethers
A Mild and Versatile Method for the Synthesis of Alkyl Ethers from MOM Ethers and Application to the Preparation of Sterically Crowded Ethers
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一种温和通用的 MOM 醚合成烷基醚的方法及其在空间拥挤醚制备中的应用
DOI：
10.1002/adsc.201200290
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发表时间：
2012
影响因子：
5.4
通讯作者：
藤岡弘道 他
中科院分区：
文献类型：
--
作者：
Tao RR;Wang H;Hong LJ;Huang JY;Lu YM;Liao MH;Ye WF;Lu NN;Zhu DY;Huang Q;Fukunaga K;Lou YJ;Shoji I;Wilcox CS;Lai EY;Han F;藤岡弘道 他
以甲氧基甲基(MOM)和甲氧基乙基(ME)醚衍生物为原料，开发了一条温和而发散的合成烷基醚的路线。将有机铜酸盐添加到盐中，即使在存在酸或碱敏感官能团的情况下，也可以高产率地提供相应的烷基醚，包括高度拥挤的烷基醚。
A mild and divergent route for the synthesis of alkyl ethers from methoxymethyl (MOM) and methoxyethyl (ME) ether derivativesviapyridinium‐type salt intermediates has been developed. The addition of organocuprates to the salts afforded the corresponding alkyl ethers, including highly crowded ones, in high yields even in the presence of acid‐ or base‐sensitive functional groups.