Physical exercise modulates the level of serum MMP-2 and MMP-9 in patients with breast cancer
Physical exercise modulates the level of serum MMP-2 and MMP-9 in patients with breast cancer
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DOI：
10.3892/ol.2016.4887
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发表时间：
2016-09-01
期刊：
影响因子：
2.9
通讯作者：
Bei, Roberto
中科院分区：
文献类型：
--
作者：
Giganti, Maria Gabriella;Tresoldi, Ilaria;Bei, Roberto
基质金属蛋白酶（Matrix metalloproteinases，MMPs）在细胞外基质降解中发挥重要作用。MMPs调节生长因子、细胞因子和转移的活化。目前，运动对血清MMP-2和MMP-9水平的影响尚不清楚。本研究的目的是调查各种体力活动对乳腺癌（BC）幸存者和健康受试者的MMP-2和-9循环水平的影响。本研究共入组66例女性受试者。该队列包括46名BC幸存者和20名健康受试者，分为5组：A组（17名BC幸存者，参加娱乐性划龙舟）、B组（14名BC幸存者，参加娱乐性体力活动）、C组（15名久坐BC幸存者）、D组（10名健康受试者，参加娱乐性体力活动）和E组（10名久坐健康受试者）。ELISA检测显示，与所有其他组相比，B组的循环MMP-2水平显著升高。在健康受试者（D组vs. E）中，仰卧体力活动增加MMP-9水平，然而，差异无统计学意义，而在BC幸存者组中，结果相反，运动降低MMP-9水平（B组vs. C）。此外，MMP-2在B组淋巴结转移阳性（N+）受试者中显著增加，与A组和C组N+受试者相比。因此，本研究的结果表明，各种体育活动调节BC幸存者中循环MMP-2和-9的水平，并且当健康受试者和BC幸存者进行相同的锻炼计划时，诱导不同的效果。这些结果可能具有重要的意义，选择适当的身体活动的BC幸存者，导致改善他们的生存和预防复发，以及改善身体功能，生活质量和疲劳。
Matrix metalloproteinases (MMPs) exhibit an important function in extracellular matrix degradation. MMPs modulate the activation of growth factors, cytokines and metastasis. At present, the effect of exercise on serum levels of MMP-2 and -9 remains unclear. The aim of the present study was to investigate the effect of various physical activities on the circulating levels of MMP-2 and -9 in breast cancer (BC) survivors and healthy subjects. A total of 66 female subjects were enrolled in the present study. The cohort included 46 BC survivors and 20 healthy subjects divided into 5 groups: Group A (17 BC survivors, participating in recreational dragon boat paddling), group B (14 BC survivors, participating in recreational physical activity), group C (15 sedentary BC survivors), group D (10 healthy subjects, participating in recreational physical activity) and group E (10 sedentary healthy subjects). ELISA assays revealed a significant increase in the level of circulating MMP-2 in group B compared with all other groups. Recreational physical activity increased the levels of MMP-9 in healthy subjects (group D vs. E), however, the differences were not statistically significant, while in the BC survivor groups the results were opposite, with exercise reducing MMP-9 levels (group B vs. C). Furthermore, a significant increase in MMP-2 was observed in group B lymph node metastasis-positive (N+) subjects compared with group A and C N+ subjects. Thus, the results of the present study indicate that various physical activities modulate the levels of circulating MMP-2 and -9 in BC survivors, and the same exercise program induces a different effect when undertaken by healthy subjects and BC survivors. These results may have important implications with regard to the selection of appropriate physical activities for BC survivors, leading to improvements to their survival and prevention of recurrence, as well as amelioration of physical function, quality of life and fatigue.