The role of colon anaerobes in the metabolism of bile acids and steroids, and its relation to colon cancer
The role of colon anaerobes in the metabolism of bile acids and steroids, and its relation to colon cancer
复制标题
结肠厌氧菌在胆汁酸和类固醇代谢中的作用及其与结肠癌的关系
作者：
M. Hill
本文综述了胆汁酸和胆固醇的取代基和核代谢的主要酶，以及它们与大肠癌病因的可能相关性。由于该疾病的发病率似乎与胆汁酸浓度以及7‐去羟化酶和Δ4‐脱氢酶的活性有关，因此强烈建议研究具有4,6‐二烯‐3‐1结构的胆汁酸。
The principle enzymes in the metabolism of both the substituent groups and the nucleus of the bile acids and of cholesterol are reviewed, together with their possible relevence to the etiology of large bowel cancer. Since the incidence of the disease appears to be related to the bile acid concentration and the activity of the 7‐dehydroxylase and the Δ4‐dehydrogenase enzymes, the study of bile acids with a 4,6‐dien‐3‐one structure is strongly recommended.