The effects and mechanisms of clinorotation on proliferation and differentiation in bone marrow mesenchymal stem cells
The effects and mechanisms of clinorotation on proliferation and differentiation in bone marrow mesenchymal stem cells
复制标题
旋转对骨髓间充质干细胞增殖分化的影响及机制
DOI：
10.1016/j.bbrc.2015.03.034
复制
发表时间：
2015
影响因子：
3.1
通讯作者：
Zhuojing Luo
中科院分区：
文献类型：
--
作者：
Ming Yan;Yongchun Wang;Min Yang;Yanwu Liu;Bo Qu;Zhengxu Ye;Wei Liang;Xiqing Sun;Zhuojing Luo
Data from human and rodent studies have demonstrated that microgravity induces observed bone loss in real spaceflight or simulated experiments. The decrease of bone formation and block of maturation may play important roles in bone loss induced by microgravity. The aim of this study was to investigate the changes of proliferation and differentiation in bone marrow mesenchymal stem cells (BMSCs) induced by simulated microgravity and the mechanisms underlying it. We report here that clinorotation, a simulated model of microgravity, decreased proliferation and differentiation in BMSCs after exposure to 48 h simulated microgravity. The inhibited proliferation are related with blocking the cell cycle in G2/M and enhancing the apoptosis. While alterations of the osteoblast differentiation due to the decreased SATB2 expression induced by simulated microgravity in BMSCs.
