Adhesive mechanisms regulating invasion and metastasis in oral cancer.
Adhesive mechanisms regulating invasion and metastasis in oral cancer.
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DOI：
10.1177/10454411010120060401
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
B. Ziober;Sol Silverman;R. Kramer
中科院分区：
文献类型：
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作者：
B. Ziober;Sol Silverman;R. Kramer
口腔鳞状细胞癌的特征是不断地侵袭和生长到周围组织。转移可能是癌症进展中最具挑战性和最重要的方面，因为它通常意味着有限的生存和无效的治疗。转移所固有的是侵袭，细胞浸润到邻近组织，降解基底膜和细胞外基质，破坏组织结构，有时甚至破坏器官功能。调节这些过程的因素是复杂的，可能涉及生理组织模型中通常存在的控制的丧失。黏附受体及其配体不仅对口腔鳞状细胞癌细胞的侵袭有重要的调节作用，而且对其存活和增殖也有重要的调节作用。正常口腔粘膜上皮细胞利用整合素维持其对基底膜的锚定，而分层细胞层的形成依赖于钙粘蛋白介导的细胞间粘连的形成。鳞状细胞癌的侵袭和传播过程需要活跃的细胞通过细胞外基质迁移，同时重建细胞间粘连。整合素在侵袭过程中显然是重要的，而细胞间粘附受体抑制侵袭并促进更分化的表型。
It is the relentless invasion and growth into surrounding tissue that characterize oral squamous cell carcinoma. Metastasis is perhaps the most challenging and important aspect of cancer progression, in that it generally signifies limited survival and ineffective therapy. Inherent in metastasis is invasion, the process by which cells infiltrate into adjacent tissues, degrading basement membranes and extracellular matrix and disrupting tissue architecture and sometimes organ function. The factors that regulate these processes are complex and likely involve loss of the controls that are normally in place in physiologic tissue modeling. Adhesion receptors and their ligands are important in modulating not only invasion of oral squamous cell carcinoma cells but also their survival and proliferation. Normal oral mucosal epithelial cells use integrins to maintain their anchorage to the basement membrane, whereas the formation of stratifying cell layers depends on the formation of intercellular adhesions mediated by cadherins. The process of squamous cell carcinoma invasion and dissemination requires active cell migration through the extracellular matrix with the simultaneous remodeling of intercellular adhesions. Integrins are clearly important in the invasive process, whereas intercellular adhesion receptors restrain invasion and promote a more differentiated phenotype.