Cranial Venous Outflow Under Lower Body Positive and Negative Pressure Conditions and Head-Up and -Down Tilts
Cranial Venous Outflow Under Lower Body Positive and Negative Pressure Conditions and Head-Up and -Down Tilts
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DOI：
10.1111/j.1552-6569.2008.00250.x
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发表时间：
2009-01-01
影响因子：
2.4
通讯作者：
Kaps, Manfred
中科院分区：
文献类型：
--
作者：
Stolz, Erwin;Fox, Bettina C.;Kaps, Manfred
虽然对动脉脑血流动力学的调节有大量的知识，但对脑静脉流出(CVO)知之甚少。对19名健康志愿者进行了经颅多普勒超声检查大脑中动脉和直窦。在下体正压(LBPP)或负压(LBNP)为30 mm Hg时，连续记录动脉和静脉平均血流速度(AFV(Mean)和VFV(Mean))，并进行头低位(-20度，HDT)和向上(+30度，HUT)倾斜动作。用无创性手指血压监测仪同时记录动脉血压。与之前的无压、无倾斜基线相比，参数的相对变化用于分析。虽然AFV(Mean)没有显著变化，但VFV(Mean)Inc.在LBPP期间下降了10.5±-2.9%，在LBNP期间下降了15.1+/-3.5%(Mean+/-Mean of Mean[SEM]，P<；.01)。HUT导致VFV(Mean)下降25.5±-3.3%，HDT增加7.8±3.2%(P<；.01)，而AFV(Mean)无明显变化。这可能意味着在下体负压和卧床期间脑血容量(CBV)减少，而在下体负压和HUT期间脑血容量增加。CVO在研究脑血流动力学时不能被忽略，因为它可能会影响CBV.J神经成像2009；19：31-36。
Although there exists a large body of knowledge on the regulation of arterial cerebral hemodynamics, little is known about the cerebral venous outflow (CVO).In 19 healthy volunteers, the middle cerebral artery and the straight sinus were examined using transcranial Doppler sonography. Arterial and venous mean flow velocities (aFV(mean), vFV(mean), respectively) were registered continuously while applying lower body positive (LBPP) or negative (LBNP) pressure of 30 mmHg and performing head-down (-20 degrees, HDT) and -up (+30 degrees, HUT) tilt manoeuvres. The arterial blood pressure was registered simultaneously with a noninvasive finger blood pressure monitor. Relative changes in parameters compared to the proceeding no-pressure, no-tilt baseline were used for analysis.While aFV(mean) did not change significantly, vFV(mean) inc reased during LBPP by 10.5 +/- 2.9% and decreased during LBNP by 15.1 +/- 3.5% (mean +/- standard error of mean [SEM], P < .01). HUT resulted in a decrease in vFV(mean) by 25.5 +/- 3.3% and HDT, in an increase by 7.8 +/- 3.2% (P < .01) without alteration in aFV(mean). This may imply a decrease of cerebral blood volume (CBV) during LBPP and HDT and an increase during LBNP and HUT.CVO cannot be neglected when studying cerebral hemodynamics because it might affect the CBV.J Neuroimaging 2009;19:31-36.