Heritability for plasma VEGF concentration in the stanislas family study
Heritability for plasma VEGF concentration in the stanislas family study
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DOI：
10.1111/j.1469-1809.2006.00298.x
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发表时间：
2007-01-01
影响因子：
1.9
通讯作者：
Visvikis-Siest, Sophie
中科院分区：
文献类型：
--
作者：
Berrahmoune, Hind;Herbeth, Bernard;Visvikis-Siest, Sophie
血管内皮生长因子（VEGF）是血管生成过程中血管功能的关键调节因子，与动脉粥样硬化、神经退行性疾病和癌症等多种疾病有关。然而，关于其在血液中浓度的遗传决定因素的数据很少。本研究的目的是估计加性遗传力，家庭成分效应和3个常见的VEGF基因多态性对血浆VEGF浓度的影响。从斯坦尼斯拉斯家庭研究中获得了160个核心家庭（647人）的随机子样本，年龄从5岁到57岁。采用多重ELISA法测定血浆VEGF浓度，采用RFLP法对VEGF基因多态性C（-460）T、G（405）C和C（936）T进行基因分型。在校正已知环境协变量的影响后，血浆VEGF浓度与家族史有显著相关性（P
Vascular endothelial growth factor ( VEGF), a key regulator of blood vessel function during angiogenesis, has been related to various diseases including atherosclerosis, neurodegenerative disorders and cancers. However, data about genetic determinants of its concentration in blood are scarce. The present study aimed at estimating additive genetic heritability, household component effect and the influence of 3 common VEGF polymorphisms on plasma VEGF concentration. A random sub-sample of 160 nuclear families (647 individuals), aging from 5 to 57, was obtained from the Stanislas Family Study. Plasma VEGF concentration was measured by a multiplexing ELISA and genotyping of the polymorphisms C(-460)T, G(405) C and C(936) T of the VEGF gene was carried out by RFLP. After adjustment for the influence of known environmental covariates, significant familial correlations were observed for plasma VEGF concentration (P