Cerebrospinal fluid pharmacokinetics of intrathecal morphine sulfate and D-Ala2-D-Leu5-enkephalin.
Cerebrospinal fluid pharmacokinetics of intrathecal morphine sulfate and D-Ala2-D-Leu5-enkephalin.
复制标题
鞘内注射硫酸吗啡和 D-Ala2-D-Leu5-脑啡肽的脑脊液药代动力学。
DOI：
10.1002/ana.410200207
复制
发表时间：
1986
影响因子：
11.2
通讯作者：
Foley,KM
中科院分区：
文献类型：
--
作者：
Moulin,DE;Inturrisi,CE;Foley,KM
Using an implantable pump system to deliver drugs and sample cerebrospinal fluid (CSF), we assessed rostral redistribution and systemic uptake after intrathecal bolus injection and steady‐state infusion of morphine sulfate and the opioid peptideD‐Ala2‐D‐Leu5‐enkephalin (DADL) in two patients. Following bolus injection, the mean CSF elimination half‐lives for morphine sulfate and DADL were 94 and 115 minutes, respectively. With the catheter tip at L2, the ratio of lumbar to cisternal (L/C) concentrations of morphine sulfate was about 7:1, and with the catheter tip at T10, the L/C ratios of morphine sulfate and DADL were approximately 2:1, indicating that this ratio is dependent in part on the level of intrathecal drug administration. CSF levels of morphine sulfate at steady state were three orders of magnitude higher than those in plasma. The CSF pharmacokinetics of morphine sulfate and DADL are similar, with supraspinal redistribution of these opioids via the CSF likely playing an important role in the generation of analgesia and central nervous system side effects.
