Unanticipated metabolic plasticity in response to chronic hypoxia.

Unanticipated metabolic plasticity in response to chronic hypoxia.
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对慢性缺氧的反应出现意想不到的代谢可塑性。

DOI:
10.1016/j.cmet.2023.02.011
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发表时间:
2023
期刊:
影响因子:
29
通讯作者:
Denko,NicholasC
Denko,NicholasC
中科院分区:
生物学1区
文献类型:
--
作者:
Papandreou,Ioanna;Benej,Martin;Denko,NicholasC

文献摘要

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在本期《细胞代谢》中,Midha等人。研究小鼠在急性或慢性暴露于低氧分压下后的代谢变化。他们的器官特异性发现可能有助于解释生活在高海拔地区的人类的生理观察,但也提出了关于血管损伤后的病理性缺氧或癌症的额外问题。
In this issue ofCell Metabolism, Midha et al. investigate the metabolic changes in mice after exposure to reduced oxygen tension for an acute or chronic duration. Their organ-specific findings may help explain physiological observations in humans living at high altitude but raise additional questions concerning pathological hypoxia after vascular damage or in cancer.