Schizophrenia hippocampus has elevated expression of chondrex glycoprotein gene
Schizophrenia hippocampus has elevated expression of chondrex glycoprotein gene
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DOI：
10.1002/syn.10228
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发表时间：
2003-10-01
期刊：
影响因子：
2.3
通讯作者：
Seeman, P
中科院分区：
文献类型：
--
作者：
Chung, C;Tallerico, T;Seeman, P
为了识别与精神分裂症相关的基因，使用DNA微阵列芯片比较精神分裂症和对照海马组织，揭示了四个表达升高的基因，chondrex（或YKL-40），组胺释放因子，HERC 2和热休克70。然而，使用定量实时聚合酶链反应方法，只有chondrex基因的表达，细胞外基质糖蛋白参与细胞生长和迁移，被发现显着升高，由1.8倍。实时PCR发现，已知与阿尔茨海默病认知缺陷相关的组胺释放因子基因的表达显著降低了19%。HERC 2和热休克70基因的表达，通过实时PCR测量，在精神分裂症海马中没有显着改变。chondrex基因表达的改变表明神经元迁移的中断可能与精神分裂症有关。组胺释放因子基因表达的改变提示该基因可能与精神分裂症学习记忆障碍的阴性症状有关。(C)2003 Wiley-Liss，Inc.
To identify genes associated with schizophrenia, DNA microarray chips were used to compare schizophrenia and control hippocampus tissues, revealing four genes with elevated expression, chondrex (or YKL-40), histamine-releasing factor, HERC2, and heat-shock 70. However, using the quantitative real-time polymerase chain reaction method, only the expression of the chondrex gene, an extracellular matrix glycoprotein involved in cell growth and migration, was found to be significantly elevated, by 1.8-fold. Real-time PCR found that the expression of the histamine-releasing factor gene, known to be associated with cognitive deficits in Alzheimer's disease, was significantly reduced by 19%. The expression of the HERC2 and heat-shock 70 genes, as measured by real-time PCR, were not significantly altered in the schizophrenia hippocampus. The altered gene expression of chondrex suggests that disruption in neuronal migration may be involved in schizophrenia. The change in expression of the histamine-releasing factor gene suggests that this gene may be associated with the negative symptoms of impaired learning and memory in schizophrenia. (C) 2003 Wiley-Liss, Inc.