Population differences in the pattern of familial aggregation for sex hormone-binding globulin and its response to exercise training: the HERITAGE Family Study.
Population differences in the pattern of familial aggregation for sex hormone-binding globulin and its response to exercise training: the HERITAGE Family Study.
复制标题
性激素结合球蛋白家族聚集模式的人群差异及其对运动训练的反应：HERITAGE 家族研究。
DOI：
10.1002/ajhb.1128
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Rao,DC
中科院分区：
文献类型：
--
作者：
An,P;Rice,T;Gagnon,J;Borecki,IB;Rankinen,T;Gu,C;Leon,AS;Skinner,JS;Wilmore,JH;Bouchard,C;Rao,DC
对基线性激素结合球蛋白(SHBG)及其对20周耐力训练计划的反应(训练后减去基线)的家庭影响进行了调查。在遗产家族研究中，来自85个黑人家庭的184名参与者使用了家族相关模型进行了分析。在基因分析之前，根据年龄、基线BMI、睾酮、雌二醇和空腹胰岛素水平(加上训练反应的基线SHBG值)对四个性别组的基线SHBG值和训练反应进行了调整。基线SHBG水平受明显的家族效应(最大遗传力h2=54%)的影响，这种相关性既不与配偶相似，也不存在性别和世代差异。这一估计仅略低于之前报道的来自99个白人家庭的428名参与者的%的遗传率，但并不显著。与遗传中的白人参与者(H2=25%)对训练反应的适度家庭影响相反，在当前的研究中，没有证据表明黑人的家庭相似。此外，黑人和白人的基线SHBG和训练反应都存在家族聚集模式的异质性。总而言之，在黑人和白人中，基线SHBG水平都受到显著的家族效应的影响，与年龄、性别以及BMI、睾酮、雌二醇和空腹胰岛素水平的基线水平的影响无关。虽然在白人的训练反应中检测到了温和的家庭影响，但在黑人中没有类似的影响，这可能是因为样本量较小。上午好。J.嗯。比奥尔。13：832-837,2001。©2001 Wiley-Liss公司
Familial influences were investigated for baseline sex hormone‐binding globulin (SHBG) and its response (post‐training minus baseline) to a 20‐week endurance exercise training program. One hundred, eighty‐four participants from 85 Black families in the HERITAGE Family Study (HERITAGE) were analyzed using a familial correlation model. Baseline SHBG values and the training response were adjusted for the effects of age, baseline BMI, testosterone, estradiol, and fasting insulin levels (plus baseline SHBG values for the training response) within four sex‐by‐generation groups prior to genetic analysis. Baseline SHBG levels were influenced by appreciable familial effects (maximum heritabilityh2= 54%) with neither spouse resemblance nor sex and generation differences in the correlations. This estimate is only slightly, but not significantly, smaller than the heritability of 64% reported previously in 428 participants from 99 White families in HERITAGE. In contrast to the modest familial effects for the training response in White participants in HERITAGE (h2= 25%), there were no evidence of familial resemblance in Blacks in the current study. Furthermore, there was heterogeneity for both baseline SHBG and the training response between Blacks and Whites in the pattern of familial aggregation. In conclusion, baseline SHBG levels are influenced by significant familial effects in both Blacks and Whites, independent of the effects of age, sex, and baseline values of BMI, testosterone, estradiol, and fasting insulin levels. Whereas modest familial effects were detected for the training response in Whites, the lack of similar effects in Blacks may be due to the smaller sample size. Am. J. Hum. Biol. 13:832–837, 2001. © 2001 Wiley‐Liss, Inc.