Comparative epidemiology of two rotavirus serotypes and other viral agents associated with pediatric gastroenteritis.
Comparative epidemiology of two rotavirus serotypes and other viral agents associated with pediatric gastroenteritis.
复制标题
与小儿胃肠炎相关的两种轮状病毒血清型和其他病毒制剂的比较流行病学。
DOI：
--
复制
发表时间：
1979
影响因子：
5
通讯作者：
R. Parrott
中科院分区：
文献类型：
--
作者：
C. Brandt;H. W. Kim;R. Yolken;A. Kapikian;J. Arrobio;W. Rodriguez;R. Wyatt;R. Chanock;R. Parrott
通过电子显微镜和/或轮状病毒ELISA，在604例胃肠炎住院患者的45.5%、200例胃肠炎门诊患者的25.0%和812例对照受试者的6.0%的粪便样本中，证实了人轮状病毒（HRV）1型或2型、腺病毒或不可培养的27 nm病毒样颗粒。华盛顿特区。轮状病毒是最常见的病原体，分别为39%和22%的胃肠炎住院患者和门诊患者，脱落HRV。大约四分之三的轮状病毒是2型，在1974年1月至1978年6月的连续五个流行年中流行。在过去连续四年的流行中检测到了HRV 1型，占1977- 1978年胃肠炎住院患者中观察到的HRV感染的近一半。这两种轮状病毒血清型最常在1月份检测到，当时123名胃肠炎住院患者中有71%和34名胃肠炎门诊患者中有62%脱落了其中一种病毒。在胃肠炎患者粪便中检测到的不可培养的腺病毒（3.9%）明显多于对照组（0.6%），表明这些病毒在急性肠道疾病中发挥了作用。27 nm颗粒的检测频率在胃肠炎和对照患者中没有显著差异。从数字上看，HRV感染最常见于10至12个月大的胃肠炎住院患者。HRV感染比例最高的胃肠炎住院患者组为13至15个月大。2型HRV感染相对于1型感染的过量在7至24个月的患者中尤其大。较低的社会经济地位或更大的拥挤似乎与轮状病毒感染的发生在生命的早期和流行年的早期。
Human rotavirus (HRV) type 1 or 2, adenovirus, or non-cultivatable 27 nm virus-like particles were demonstrated by electron microscopy and/or rotavirus ELISA in fecal samples from 45.5% of 604 gastroenteritis inpatients, 25.0% of 200 gastroenteritis outpatients and 6.0% of 812 control subjects, all sampled at Children's Hospital National Medical Center. Washington, DC. Rotaviruses were the most common pathogens detected as 39% and 22% of gastroenteritis inpatients and outpatients, respectively, shed HRV. About three-fourths of the rotaviruses were type 2, which was prevalent during five successive epidemic years from January, 1974, through June, 1978. HRV type 1 was detected in the last four successive epidemic years and represented nearly half of the HRV infections observed among gastroenteritis inpatients during the year 1977--1978. Both rotavirus serotypes were detected most often in the month of January, when 71% of 123 gastroenteritis inpatients and 62% of 34 gastroenteritis outpatients shed one of these viruses. Uncultivatable adenoviruses were detected significantly more frequently in stools from patients with gastroenteritis (3.9%) than from control subjects (0.6%), suggesting that these viruses played a role in acute enteric disease. The frequency of detection of 27 nm particles was not significantly different in gastroenteritis and control patients. Numerically, HRV infection was detected most often in gastroenteritis inpatients who were 10 through 12 months of age. The group of gastroenteritis inpatients with the highest percentage of HRV infection was 13 through 15 months of age. The excess of type 2 HRV infection relative to type 1 infection was especially large in those aged 7 through 24 months. Lower socioeconomic status or greater crowding appeared to be associated with the occurrence of rotavirus infection earlier in life and earlier in the epidemic year.