Phenotype profiling of Modic changes of the lumbar spine and its association with other MRI phenotypes: a large-scale population-based study
Phenotype profiling of Modic changes of the lumbar spine and its association with other MRI phenotypes: a large-scale population-based study
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DOI：
10.1016/j.spinee.2015.06.056
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发表时间：
2015-09-01
期刊：
影响因子：
4.5
通讯作者：
Samartzis, Dino
中科院分区：
文献类型：
--
作者：
Maatta, Juhani H.;Karppinen, Jaro I.;Samartzis, Dino
背景：Modic改变（MC）与下背痛相关。它们代表了磁共振成像（MRI）上椎体终板和相邻椎体骨髓的变化，分为三种类型。由于样本量小，患者队列和有限的表型评估，MC的形态和参与及其与其他脊柱表型的关系仍然是推测性的。目的：我们在一项大规模的基于人群的研究中提出并提出了MC的表型特征及其与腰椎MRI表型的关系。研究设计/设置：香港椎间盘退变队列的横断面研究。患者样本：研究人群包括1,546名中国南方志愿者。结果：MC的地形和形态尺寸，椎间盘退变（DD）和位移的存在，以及Schmorl nodes. METHODS：轴向T1加权和矢状位T2加权MRI（3 T）进行了评估。MC的总患病率为21.9%（6.3% I型和15.5% II型）。在所有MC中，76%位于两个最低腰椎节段。最低两个腰椎节段的Modic改变更常见于外侧（p
BACKGROUND CONTEXT: Modic changes (MC) are associated with low back pain. They represent vertebral endplate and adjacent vertebral marrow changes on magnetic resonance imaging (MRI), classified into three types. Because of small sample sizes, patient cohorts, and limited phenotype assessment, the morphology and involvement of MC and their association with other spinal phenotypes remain speculative.PURPOSE: We addressed and proposed a phenotypic profiling of MC and their relationship with lumbar MRI phenotypes in a large-scale population-based study.STUDY DESIGN/SETTING: A cross-sectional study of the Hong Kong Disc Degeneration Cohort.PATIENT SAMPLE: The study population consisted of 1,546 Southern Chinese volunteers.OUTCOME MEASURES: Topographical and morphological dimensions of MC, presence of disc degeneration (DD) and displacement, and Schmorl nodes were evaluated.METHODS: Axial T1-weighted and sagittal T2-weighted MRIs (3T) were assessed.RESULTS: Females were 62.4% (mean age, 49 years). The overall prevalence of MC was 21.9% (6.3% Type I and 15.5% Type II). Of all MC, 76% were located at the two lowest lumbar levels. Modic changes at the two lowest lumbar levels were more commonly located laterally (p