Prostaglandin catabolizing enzymes
Prostaglandin catabolizing enzymes
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DOI：
10.1016/s0090-6980(02)00050-3
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发表时间：
2002-08-01
影响因子：
2.9
通讯作者：
Yan, FX
中科院分区：
文献类型：
--
作者：
Tai, HH;Ensor, CM;Yan, FX
前列腺素及相关类20蛋白的主要分解代谢途径是由NAD（+）依赖的15-羟基前列腺素脱氢酶（15- pgdh）催化15(S)-羟基氧化，然后由NADPH/NADH依赖的δ(13)-15-酮前列腺素还原酶（13- pgr）催化A - 13双键还原。13-PGR还显示NADP（+）依赖性白三烯B-4 12-羟基脱氢酶（12-LTB4DH）活性。这些酶被认为是负责前列腺素和相关二十烷类生物失活的关键酶。血栓素的另一个分解代谢途径是由NAD（+）依赖的I-羟基血栓素B2脱氢酶（11-TXB2DH）在C-I位点氧化血栓素B-2 （TXB2）。该反应的产物I-脱氢- txb2被认为是循环中血栓素形成的更可靠的定量指标。近年来的生物化学和分子生物学研究揭示了这三种酶的催化特性、结构和活性关系以及基因表达的调控。未来的研究可能会进一步阐明这些酶在健康和疾病中的作用。(C) 2002爱思唯尔科学有限公司版权所有。
The primary catabolic pathway of prostaglandins and related eicosanoids is initiated by the oxidation of 15(S)-hydroxyl group catalyzed by NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) followed by the reduction of A 13 double bond catalyzed by NADPH/NADH dependent Delta(13)-15-ketoprostaglandin reductase (13-PGR). 13-PGR was also found to exhibit NADP(+)-dependent leukotriene B-4 12-hydroxydehydrogenase (12-LTB4DH) activity. These enzymes are considered to be the key enzymes responsible for biological inactivation of prostaglandins and related eicosanoids. A separate catabolic pathway of thromboxane involves the oxidation of thromboxane B-2 (TXB2) at C-I I catalyzed by NAD(+)-dependent I-hydroxythromboxane B2 dehydrogenase (11-TXB2DH). The product of this reaction, I I-dehydro-TXB2, has been considered to be a more reliable quantitative index of thromboxane formation in the circulation. Recent biochemical and molecular biological studies have revealed interesting catalytic properties, structure, and activity relationship, and regulation of gene expression of these three enzymes. Future investigation may shed more light on the roles of these enzymes in health and diseases. (C) 2002 Elsevier Science Inc. All rights reserved.