Comparison of optical coherence tomography and intravascular ultrasound for evaluation of coronary lipid-rich atherosclerotic plaque progression and regression
Comparison of optical coherence tomography and intravascular ultrasound for evaluation of coronary lipid-rich atherosclerotic plaque progression and regression
复制标题
光学相干断层扫描和血管内超声评估冠状动脉富含脂质的动脉粥样硬化斑块进展和消退的比较
DOI：
10.1093/ehjci/jev104
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发表时间：
2015-12-01
影响因子：
6.2
通讯作者：
Yu, Bo
中科院分区：
文献类型：
--
作者：
Xie, Zulong;Tian, Jinwei;Yu, Bo
目的与血管内超声（IVUS）相比，光学相干断层扫描（OCT）在检测斑块特征方面有其优缺点。目前尚不清楚IVUS和OCT对斑块进展/消退的评价是否一致。我们试图分析IVUS和OCT评价斑块在单个时间点之间的相关性，并比较IVUS和OCT data.Methods和结果的时间变化，从65例冠状动脉疾病患者的88个富含脂质的斑块与IVUS和OCT在基线和12个月的随访进行了分析。OCT显示的纤维帽厚度与IVUS显示的动脉粥样硬化总体积呈负相关（r = 20.28，P = 0.009），但与动脉粥样硬化体积百分比无关（P = 0.84）。OCT变化与IVUS变化无显著相关性。IVUS显示进展、消退或无变化的斑块在OCT参数纤维帽厚度（P = 0.199）、最大脂质核心弧（P = 0.755）、平均脂质核心弧（P = 0.936）和脂质指数（P = 0.91）变化方面无差异。3组斑块中薄帽纤维粥样硬化（TCFA）的发生率在基线（P = 0.79）和随访（P = 0.609）时无显著性差异。结论尽管OCT上纤维帽厚度与IVUS上斑块大小在单个时间点呈负相关，但OCT参数的变化与IVUS测量值随时间的变化无关。IVUS上的病变进展/消退与OCT参数（纤维帽厚度、脂质核心弧、脂质指数和TCFA）的变化无关。
Aims Compared with intravascular ultrasound (IVUS), optical coherence tomography (OCT) has relative merits and demerits for detecting plaque characteristics. It remains unknown whether the IVUS and OCT evaluations of plaque progression/regression are consistent. We sought to analyse the correlations between IVUS and OCT evaluations of plaques at single time points, and compare temporal changes in the IVUS and OCT data.Methods and results Eighty-eight lipid-rich plaques from 65 patients with coronary artery disease were analysed with IVUS and OCT at baseline and 12-month follow-up. Fibrous cap thickness on OCT was negatively correlated with total atheroma volume on IVUS (r = 20.28, P = 0.009), but not with percent atheroma volume (P = 0.84). Changes on OCT were not significantly correlated with changes on IVUS. Plaques that showed progression, regression, or no change on IVUS showed no differences in terms of changes in the OCT parameters fibrous cap thickness (P = 0.199), maximum lipid core arc (P = 0.755), mean lipid core arc (P = 0.936), and lipid index (P = 0.91). The incidence of thin-cap fibroatheroma (TCFA) was similar among the above three plaque groups at baseline (P = 0.79) and follow-up (P = 0.609).Conclusion Although fibrous cap thickness on OCT was negatively correlated with plaque size on IVUS at single time points, changes in OCT parameters were not correlated with changes in IVUS measures over time. Lesion progression/regression on IVUS was not associated with changes in OCT parameters (fibrous cap thickness, lipid core arc, lipid index, and TCFA).