Initial Recovery and Rebound of Type F Intestinal Colonization Botulism After Administration of Investigational Heptavalent Botulinum Antitoxin
Initial Recovery and Rebound of Type F Intestinal Colonization Botulism After Administration of Investigational Heptavalent Botulinum Antitoxin
复制标题
DOI：
10.1093/cid/cir550
复制
发表时间：
2011-11-01
影响因子：
11.8
通讯作者：
Khalil, Wajahat
中科院分区：
文献类型：
--
作者：
Fagan, Ryan P.;Neil, Karen P.;Khalil, Wajahat
研究中的七价肉毒抗毒素(HBAT)现在是美国非婴儿肉毒中毒患者的主要抗毒素。HBAT由马Fab/F(ab‘)2免疫球蛋白片段组成，它们从循环中清除的速度比整个免疫球蛋白快。抗毒素注射后的反弹肉毒杆菌中毒以前没有文献记载，但我们的患者在注射HBAT 10天后发生。
Investigational heptavalent botulinum antitoxin (HBAT) is now the primary antitoxin for US noninfant botulism patients. HBAT consists of equine Fab/F(ab')2 IgG fragments, which are cleared from circulation faster than whole immunoglobulins. Rebound botulism after antitoxin administration is not previously documented but occurred in our patient 10 days after HBAT administration.