[Molecular basis of carcinogenesis in lung cancer induced by cigarette smoking].
[Molecular basis of carcinogenesis in lung cancer induced by cigarette smoking].
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发表时间：
2001-06
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影响因子：
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通讯作者：
I. Damps;E. Jassem;A. Siemińska
中科院分区：
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作者：
I. Damps;E. Jassem;A. Siemińska
本文综述了吸烟与肺癌发生之间的关系。肿瘤发展的“个体易感性”极有可能存在，并且与编码酶的基因的多态性变体有关，所述酶用于异生物质物质的代谢。由于代谢过程的改变，高活性分子的聚集导致DNA加合物的形成和突变趋势的增加。负责增殖、细胞周期停滞、凋亡和DNA损伤修复的基因组经常被改变。
An association between cigarette smoking and lung cancer carcinogenesis is reviewed. It is highly possible, that "individual susceptibility" for tumor development exists and is related to polymorphic variants of genes encoding for enzymes, which are employed in metabolism of xenobiotic substances. The gathering of highly reactive molecules due to modified metabolic processes results in DNA adducts forming and increased tendency for mutations. Group of genes, responsible for proliferation, cell cycle arrest, apoptosis and DNA damage repair are frequently altered.