OUTCOME ASSESSMENT FOR EPILEPSY SURGERY - THE IMPACT OF MEASURING HEALTH-RELATED QUALITY-OF-LIFE
OUTCOME ASSESSMENT FOR EPILEPSY SURGERY - THE IMPACT OF MEASURING HEALTH-RELATED QUALITY-OF-LIFE
复制标题
DOI：
10.1002/ana.410370205
复制
发表时间：
1995-02-01
影响因子：
11.2
通讯作者：
BROOK, RH
中科院分区：
文献类型：
--
作者：
VICKREY, BG;HAYS, RD;BROOK, RH
癫痫手术是一种越来越常见的治疗顽固性癫痫的方法；然而，对于如何报告癫痫手术结果，专家们并没有明确的共识。大多数已发表的结果报告系统侧重于癫痫发作的频率和类型，但在如何定义临床上不同的结果类别上有所不同。我们使用可靠和有效的自我报告的健康相关生活质量(HRQOL)测量，癫痫手术问卷(ESI)-55，作为一个外部标准，用来评估之前发表的七个基于癫痫的结果分类系统。对133名之前因顽固性癫痫接受手术的成年人进行了ESI-55测试，结果与他们手术前后(在他们的HRQOL报告之前一年内)癫痫发作的数据有关。这133名患者根据每个基于癫痫发作的结果系统进行分类，并通过方差分析评估不同结果组之间的HRQOL差异。结果显示，在不同系统反映患者在随访时的HRQOL的程度上存在显著差异。我们对现有的系统进行了修改，以得出一个基于癫痫的手术结果系统，当应用于最近一年的术后间隔时，该系统最接近地反映了HRQOL。
Epilepsy surgery is an increasingly common treatment for intractable epilepsy; yet there is no clear consensus among experts on how to report epilepsy surgery outcome. Most published outcome reporting systems focus on seizure frequency and type but differ in how they define clinically distinct outcome categories. We used a reliable and valid measure of self-reported health-related quality of life (HRQOL), the Epilepsy Surgery Inventory (ESI)-55, as an external standard by which to evaluate seven previously published, seizure-based outcome classification systems. The ESI-55 was administered to 133 adults who had previously undergone surgery for intractable epilepsy, and results were linked to data on their seizure occurrence before and after surgery (over the year prior to their HRQOL reports). These 133 patients were classified according to each seizure-based outcome system, and variation in HRQOL across outcome groups was evaluated using analysis of variance. Results reveal noteworthy variation in the extent to which different systems reflect patients' HRQOL at follow-up. We modifed existing systems to derive a seizure-based surgery outcome system that most closely reflects HRQOL when applied over the latest 1-year postoperative interval.