Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer.
Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer.
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DOI：
10.1042/bsr20130062
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发表时间：
2013-08-23
影响因子：
4
通讯作者：
Escande C
中科院分区：
文献类型：
--
作者：
Chini EN;Chini CC;Nin V;Escande C
DBC1（在乳腺癌中缺失 - 1）是一种调节细胞代谢的核蛋白。由于细胞代谢的改变已被认为是癌症新兴的“标志”，所以DBC1可能参与癌细胞能量代谢的调节。然而，在此刻，DBC1在癌症中的任何作用都只是推测性的。在这篇综述中，我们将讨论DBC1研究的新进展、其分子结构、调节作用以及在代谢、衰老和癌症中的影响。
DBC1 (deleted in breast cancer-1) is a nuclear protein that regulates cellular metabolism. Since alteration in cellular metabolism have been proposed to be the emerging ‘hallmark’ of cancer, it is possible that DBC1 may be implicated in the regulation of cancer cell energy metabolism. However, at this point any role of DBC1 in cancer is only speculative. In this review, we will discuss the new developments in DBC1 research, its molecular structure, regulatory roles and implication in metabolism, aging and cancer.