Increasing pregnancy-related use of prescribed opioid analgesics.
Increasing pregnancy-related use of prescribed opioid analgesics.
复制标题
DOI：
10.1016/j.annepidem.2013.05.017
复制
发表时间：
2013-08
影响因子：
5.6
通讯作者：
Cooper, William O.
中科院分区：
文献类型：
--
作者：
Epstein, Richard A.;Bobo, William V.;Martin, Peter R.;Morrow, James A.;Wang, Wei;Chandrasekhar, Rameela;Cooper, William O.
量化1995年至2009年参加田纳西州医疗补助计划的孕妇中处方阿片类镇痛药的患病率。回顾性队列研究277，555例从出生和胎儿死亡证明中识别的妊娠，并与先前验证的计算机化药房记录相关联。泊松回归用于估计随时间的趋势、率比和95%置信区间。在研究期间，29%的孕妇服用了阿片类镇痛药。从1995年到2009年，任何妊娠相关的使用增加了1.90倍（95% CI = 1.83，1.98），妊娠早期使用增加了2.27倍（95% CI = 2.14，2.41），妊娠中期或妊娠晚期使用增加了2.02倍（95% CI = 1.93，2.12），调整后的母亲特征。任何与怀孕有关的，前三个月，中三个月或后三个月的使用在至少21岁，白色，非西班牙裔，初孕，居住在非城市地区，因残疾参加医疗补助，以及高中教育程度以下的母亲中更有可能。从1995年到2009年，田纳西州医疗补助保险孕妇使用阿片类镇痛药的人数增加了近2倍。为了了解这种增加使用的影响，需要进行进一步的研究。
To quantify the prevalence of prescribed opioid analgesics among pregnant women enrolled in Tennessee Medicaid from 1995 to 2009. Retrospective cohort study of 277,555 pregnancies identified from birth and fetal death certificates, and linked to previously-validated computerized pharmacy records. Poisson regression was used to estimate trends over time, rate ratios and 95% confidence intervals. During the study period, 29% of pregnant women filled a prescription for an opioid analgesic. From 1995 to 2009, any pregnancy-related use increased 1.90-fold (95% CI = 1.83, 1.98), first trimester use increased 2.27-fold (95% CI = 2.14, 2.41), and second or third trimester use increased 2.02-fold (95% CI = 1.93, 2.12), after adjusting for maternal characteristics. Any pregnancy-related, first trimester, and second or third trimester use were each more likely among mothers who were at least 21 years old, white, non-Hispanic, prima gravid, resided in non-urban areas, enrolled in Medicaid due to disability, and who had less than a high school education. Opioid analgesic use by Tennessee Medicaid-insured pregnant women increased nearly 2-fold from 1995 to 2009. Additional study is warranted in order to understand the implications of this increased use.
登录
查看更多内容
影响因子：
9.8
作者：
Broussard, Cheryl S.;Rasmussen, Sonja A.;Honein, Margaret A.
通讯作者：
Honein, Margaret A.
影响因子：
4
作者：
Braden, Jennifer Brennan;Fan, Ming-Yu;Sullivan, Mark D.
通讯作者：
Sullivan, Mark D.
影响因子：
9.8
作者：
Bowen, Michael E.;Ray, Wayne A.;Cooper, William O.
通讯作者：
Cooper, William O.
影响因子：
9.8
作者：
Cooper, William O.;Willy, Mary E.;Ray, Wayne A.
通讯作者：
Ray, Wayne A.
影响因子：
7.4
作者：
Caudill-Slosberg, MA;Schwartz, LM;Woloshin, S
通讯作者：
Woloshin, S