Impact of factors affecting the residual tumor size diagnosed by MRI following neoadjuvant chemotherapy in comparison to pathology.
Impact of factors affecting the residual tumor size diagnosed by MRI following neoadjuvant chemotherapy in comparison to pathology.
复制标题
DOI：
10.1002/jso.23470
复制
发表时间：
2014-02
影响因子：
2.5
通讯作者：
Su, Min-Ying
中科院分区：
文献类型：
--
作者：
Chen, Jeon-Hor;Bahri, Shadfar;Mehta, Rita S.;Carpenter, Philip M.;Mclaren, Christine E.;Chen, Wen-Pin;Fwu, Peter T.;Hsiang, David J. B.;Lane, Karen T.;Butler, John A.;Su, Min-Ying
探讨磁共振成像（MRI）测量接受新辅助化疗（NAC）的乳腺癌患者残留肿瘤大小的准确性。研究了98例患者。在NAC期间进行多次MRI以监测反应，并在完成NAC后的最后一次MRI上测量残留肿瘤大小。分析协变量，包括年龄、肿瘤特征、生物标志物、NAC方案、MRI扫描仪和从上次MRI到手术的时间。使用单变量和多变量线性回归模型确定这些协变量对MRI-病理学尺寸差异的预测值作为结局指标。MRI和病理学残留肿瘤大小之间的绝对差的平均值（±SD）为1.0 ± 2.0 cm（范围，0-14 cm）。单因素回归分析显示肿瘤类型、形态、HR状态、HER 2状态、MRI扫描仪（1.5T或3.0T）与MRI-病理大小差异显著相关（均P < 0.05）。多变量回归分析表明，只有肿瘤类型、肿瘤形态和生物标志物状态（同时考虑HR和HER-2）是独立的预测因子（分别为P = 0.0014、0.0032和0.0286）。MRI评估残留肿瘤大小的准确性取决于肿瘤类型、形态和生物标志物状态。这些信息可以在NAC患者的手术计划中考虑。
To investigate accuracy of magnetic resonance imaging (MRI) for measuring residual tumor size in breast cancer patients receiving neoadjuvant chemotherapy (NAC). Ninety-eight patients were studied. Several MRI were performed during NAC for response monitoring, and the residual tumor size was measured on last MRI after completing NAC. Covariates, including age, tumor characteristics, biomarkers, NAC regimens, MRI scanners, and time from last MRI to operation, were analyzed. Univariate and Multivariate linear regression models were used to determine the predictive value of these covariates for MRI-pathology size discrepancy as the outcome measure. The mean (±SD) of the absolute difference between MRI and pathological residual tumor size was 1.0 ± 2.0 cm (range, 0–14 cm). Univariate regression analysis showed tumor type, morphology, HR status, HER2 status, and MRI scanner (1.5 T or 3.0 T) were significantly associated with MRI-pathology size discrepancy (all P < 0.05). Multivariate regression analyses demonstrated that only tumor type, tumor morphology, and biomarker status considering both HR and HER-2 were independent predictors (P = 0.0014, 0.0032, and 0.0286, respectively). The accuracy of MRI in evaluating residual tumor size depends on tumor type, morphology, and biomarker status. The information may be considered in surgical planning for NAC patients.
登录
查看更多内容
影响因子：
3.7
作者：
Ko, Eun Sook;Han, Boo-Kyung;Park, Yeon Hee
通讯作者：
Park, Yeon Hee
影响因子：
6.2
作者：
Chen, Jeon Hor;Feig, Lyon;Su, Min Ying
通讯作者：
Su, Min Ying
影响因子：
6.2
作者：
Ishitobi, Makoto;Ohsumi, Shozo;Oura, Shoji
通讯作者：
Oura, Shoji
影响因子：
3.1
作者：
Kuzucan A;Chen JH;Bahri S;Mehta RS;Carpenter PM;Fwu PT;Yu HJ;Hsiang DJ;Lane KT;Butler JA;Feig SA;Su MY
通讯作者：
Su MY
影响因子：
3.8
作者：
Cebrecos, I.;Cordoba, O.;Rubio, I. T.
通讯作者：
Rubio, I. T.