Comparative anatomy of the subsynovial connective tissue in the carpal tunnel of the rat, rabbit, dog, baboon, and human.
Comparative anatomy of the subsynovial connective tissue in the carpal tunnel of the rat, rabbit, dog, baboon, and human.
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DOI：
10.1007/s11552-006-9009-z
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发表时间：
2006-12-01
期刊：
影响因子：
--
通讯作者：
Amadio, Peter C
中科院分区：
文献类型：
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作者：
Ettema, Anke M;Zhao, Chunfeng;Amadio, Peter C
腕管中的腱鞘通过滑膜下结缔组织（SSCT）与屈肌腱和正中神经相连。腕管综合征（CTS）是一种压迫正中神经的神经病变，最常见的组织学发现是SSCT的非炎症性纤维化。纤维化与神经病理之间的关系尚不清楚，尽管一些人推测SSCT体积或硬度的变化可能是压迫的来源。然而，虽然动物模型已被用于研究神经压迫的生理学，但尚未有动物模型用于研究SSCT病理与神经生理异常的关系。本研究的目的是寻找合适的动物模型来研究SSCT与神经功能在CTS发展过程中的相互作用。老鼠、兔子、狗和狒狒的前爪被解剖。光镜和扫描显微镜下观察腕管解剖和SSCT，并与人体相关解剖和超微结构进行比较。狒狒和兔子的腕管解剖结构和内容物与人类相似。犬腕管缺乏浅表屈肌腱，大鼠腕管非常小。人类、狒狒和家兔的SSCT组织和腕管内容非常相似。我们的结论是，虽然狒狒和兔子都是研究SSCT与CTS关系的良好动物模型，但从成本和动物护理方面考虑，兔子可能更实用。
The tenosynovium in the human carpal tunnel is connected to the flexor tendons and the median nerve by the subsynovial connective tissue (SSCT). The most common histological finding in carpal tunnel syndrome (CTS), a compression neuropathy of the median nerve, is noninflammatory fibrosis of the SSCT. The relationship, if any, between the fibrosis and nerve pathology is unknown, although some have speculated that a change in the SSCT volume or stiffness might be the source of the compression. Yet, while animal models have been used to study the physiology of nerve compression, so far none have been used to study the relationship of the SSCT pathology to the neurophysiological abnormalities. The purpose of this study was to identify animal models that might be appropriate to study the interaction of SSCT and nerve function in the development of CTS. The front paws of a rat, rabbit, dog, and baboon were dissected. The carpal tunnel anatomy and SSCT of these animals were also examined by light and scanning microscopy and compared to the relevant human anatomy and ultrastructure. The carpal tunnel anatomy and contents of the baboon and rabbit are similar to humans. The canine carpal tunnel lacks the superficial flexor tendons and the rat carpal tunnel is very small. The human, baboon, and rabbit specimens had very similar organization of the SSCT, and content of the carpal canal. We conclude that, while both the baboon and rabbit would be good animal models to study the relationship of the SSCT to CTS, the rabbit is likely to be more practical, in terms of cost and animal care concerns.