B-CELL IMMUNODEFICIENCY IN ACQUIRED IMMUNE-DEFICIENCY SYNDROME
B-CELL IMMUNODEFICIENCY IN ACQUIRED IMMUNE-DEFICIENCY SYNDROME
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DOI：
10.1001/jama.251.11.1447
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发表时间：
1984-01-01
影响因子：
120.7
通讯作者：
CONANT, M
中科院分区：
文献类型：
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作者：
AMMANN, AJ;SCHIFFMAN, G;CONANT, M
为探讨获得性免疫缺陷综合征(AIDS)患者的B细胞功能，用肺炎球菌多糖(十四价)和蛋白(锁孔-帽状血蓝蛋白)抗原免疫一组艾滋病患者。免疫后3~4wk测定抗体反应。与对照组相比，艾滋病患者免疫前后抗多糖抗体几何平均水平显著降低。免疫前后的水平经常低于被认为与保护相关的水平。艾滋病患者对蛋白质抗原的主要抗体反应也显著降低。因此，艾滋病与获得性B细胞和T细胞免疫缺陷有关。今后的研究应考虑评价被动抗体在预防感染和/或预防进行性免疫缺陷中的作用。
To investigate B-cell function in acquired immune deficiency syndrome (AIDS), a group of patients with AIDS was immunized with pneumococcal polysaccharide (tetradecavalent) and protein (keyhole-limpet hemocyanin) antigens. Antibody responses were determined 3-4 wk after immunization. Compared with controls, patients with AIDS had significantly lower geometric mean antibody levels to polysaccharide before and after immunization. Levels before and after immunization were frequently below a level thought to correlate with protection. Patients with AIDS also had a significant reduction in their primary antibody response to the protein antigens. Thus, AIDS is associated with an acquired B-cell and T-cell immunodeficiency. Future studies should consider the evaluation of passive antibody in the prevention of infection and/or prevention of progressive immunodeficiency.