A CORRELATIVE ANATOMICAL AND CLINICAL-STUDY OF PAIN SUPPRESSION BY DEEP BRAIN-STIMULATION
A CORRELATIVE ANATOMICAL AND CLINICAL-STUDY OF PAIN SUPPRESSION BY DEEP BRAIN-STIMULATION
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DOI：
10.1016/0304-3959(82)90022-7
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发表时间：
1982-01-01
期刊：
影响因子：
7.4
通讯作者：
MEYERSON, BA
中科院分区：
文献类型：
--
作者：
BOIVIE, J;MEYERSON, BA
电刺激丘脑内侧区治疗癌性疼痛的临床效果与刺激点的准确位置有关。对5例脑组织进行尸检。长达17个月的釉质镀铂-铱电极的慢性植入。引起相对轻微的神经胶质反应和神经元反应，无明显出血或脑梗塞。解剖学验证表明，电极接近于立体定向坐标定义的区域，但并不完全在该区域内。从临床解剖学的相关性来看，电刺激丘脑后部的脑室周围灰质区似乎可以获得良好的止痛效果。
The clinical results of electrical stimulation in medial thalamic regions for cancer pain have been correlated with the exact location of the stimulation sites. Five brains were examined by postmortem histology. Chronic implantation of enamel coated platinum-iridium electrodes for up to 17 mo. caused relatively mild glial and neuronal reactions, and no significant hemorrhage or infarction. The anatomical verifications showed that the electrodes were close to, but not exactly in, the regions defined by the stereotactic coordinates. From the clinico-anatomical correlations it appears that good pain relief can be obtained by electrical stimulation in the periventricular gray region of the posterior thalamus.