Neurocognitive correlates of type 1 diabetes mellitus in childhood
Neurocognitive correlates of type 1 diabetes mellitus in childhood
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DOI：
10.1076/chin.10.1.36.26241
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发表时间：
2004-03-01
影响因子：
2.2
通讯作者：
Rovet, J
中科院分区：
文献类型：
--
作者：
Desrocher, M;Rovet, J
1型糖尿病（T1DM）是18岁以下儿童中最常见的慢性健康状况之一。该疾病的并发症包括低血糖和高血糖，这可能会影响儿童在评估情况下，在诊所和学校的表现。由于这种疾病无法治愈，因此需要了解与其某些并发症相关的认知缺陷，因为这些知识将影响治疗方案的选择以及教育干预措施。本文对T1DM神经认知结局的相关文献进行了全面综述。特别是，将审查与认知领域表现不佳相关的疾病和治疗相关变量。具体而言，将检查发病年龄、持续时间、青春期影响以及是否存在低血糖或高血糖。这些发现并非没有争议，结论的局限性也将提出。在相关的情况下，将提供未来研究方向的建议。
Type 1 Diabetes Mellitus (T1DM) is one of the most prevalent chronic health conditions in children under the age of 18 years. Complications of the disease include hypo- and hyperglycemia, which can have an impact on children's performance in assessment situations, in the clinic, and in school. Because there is no cure for this disease, there is a need to understand the cognitive deficits associated with some of its complications, as this knowledge will impact on the choice of treatment regimens as well as educational interventions. This paper provides a comprehensive review of the relevant literature on the neurocognitive outcome of T1DM. In particular, disease- and treatment-related variables that are associated with poor performance on cognitive domains will be reviewed. Specifically, age of onset, duration, pubertal effects, and presence of hypoglycemia or hyperglycemia will be examined. These findings are not without controversy, and limitations to conclusions will also be presented. Where relevant, recommendations for future research directions will be provided.