LOCALIZATION OF SEROTONIN-LIKE IMMUNOREACTIVITY IN THE MERKEL CELLS OF PIG SNOUT SKIN
LOCALIZATION OF SEROTONIN-LIKE IMMUNOREACTIVITY IN THE MERKEL CELLS OF PIG SNOUT SKIN
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DOI：
10.1002/ar.1092250402
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发表时间：
1989-12-01
影响因子：
--
通讯作者：
BEIRAS, A
中科院分区：
文献类型：
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作者：
GARCIACABALLERO, T;GALLEGO, R;BEIRAS, A
通过过氧化物酶-抗过氧化物酶免疫组织化学技术研究了猪口鼻表皮默克尔细胞中血清素的存在。血清素样免疫反应性默克尔细胞被发现位于表皮网钉底部和窦毛囊（触毛）的外根鞘中。默克尔细胞基底侧的免疫反应性更强，那里的致密核心颗粒最多。与默克尔细胞相关的神经末梢和邻近的表皮细胞均未进行免疫染色。这些结果是哺乳动物默克尔细胞中血清素样免疫反应性的第一个证据。事实上，默克尔细胞中颗粒密度最高的部分的免疫反应性最强，这表明在这些细胞中，血清素可能位于致密核心颗粒中。
The presence of serotonin in the Merkel cells of pig snout epidermis was investigated by the peroxidase-antiperoxidase immunohistochemical technique. Serotonin-like immunoreactive Merkel cells were found in groups located at the base of epidermal rete pegs and in the external root sheath of sinus hair follicles (vibrissae). Immunoreactivity was stronger on the basal side of the Merkel cells, where dense-cored granules are most numerous. Neither the nerve terminal associated with the Merkel cell nor the neighbouring epidermal cells were immunostained. These results are the first evidence of serotonin-like immunoreactivity in mammalian Merkel cells. The fact that immunoreactivity is strongest in those parts of the Merkel cells with the highest granule density suggests that in these cells serotonin is probably localized in the dense-cored granules.