N-methyl-D-aspartate receptors in the basolateral amygdala are required for both acquisition and expression of conditional fear in rats
N-methyl-D-aspartate receptors in the basolateral amygdala are required for both acquisition and expression of conditional fear in rats
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DOI：
10.1037/0735-7044.110.6.1365
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发表时间：
1996-12-01
影响因子：
1.9
通讯作者：
Fanselow, MS
中科院分区：
文献类型：
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作者：
Maren, S;Aharonov, G;Fanselow, MS
三个实验考察了杏仁核内注射N-甲基-D-天冬氨酸受体拮抗剂D，L-2-氨基-5-磷酸戊酸对大鼠背景恐惧条件反射的影响。在实验1中，在训练前将APV注入杏仁基底外侧核(BLA)，扰乱了背景恐惧的获得。在实验2中，APV对背景恐惧的获得和表达都产生了干扰。这种背景恐惧的阻断不是状态依赖的，不是由于足部电击敏感度的改变，也不是APV治疗大鼠运动活动增加的结果。在实验3中，恐惧条件反射不受训练后APV注入BLA的影响。这些结果表明，BLA中的NMDA受体对于大鼠对情境线索的巴甫洛夫恐惧条件反射的获得和表达都是必要的。
Three experiments examined the effects of intra-amygdaloid infusions of an N-methyl-D-aspartate (NMDA) receptor antagonist, D,L-2-amino-5-phosphonovalerate (APV), on contextual fear conditioning in rats. In Experiment 1, APV infusion into the basolateral amygdala (BLA), before training, disrupted the acquisition of contextual fear. In Experiment 2, APV produced a disruption of both the acquisition and expression of contextual fear. This blockade of contextual fear was not state dependent, not due to a shift in footshock sensitivity, and not the result of increased motor activity in APV-treated rats. In Experiment 3, fear conditioning was not affected by a posttraining APV infusion into the BLA. These results indicate that NMDA receptors in the BLA are necessary for both the acquisition and expression of Pavlovian fear conditioning to contextual cues in rats.