INCREASED ADIPOSE-TISSUE LIPOPROTEIN-LIPASE ACTIVITY DURING DEVELOPMENT OF GENETICALLY OBESE RAT (FA-FA)
INCREASED ADIPOSE-TISSUE LIPOPROTEIN-LIPASE ACTIVITY DURING DEVELOPMENT OF GENETICALLY OBESE RAT (FA-FA)
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DOI：
10.1016/s0026-0495(78)80012-2
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发表时间：
1978-01-01
影响因子：
9.8
通讯作者：
GREENWOOD, MRC
中科院分区：
文献类型：
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作者：
GRUEN, R;HIETANEN, E;GREENWOOD, MRC
测定了肥胖和消瘦Zucker大鼠附睾脂肪组织中脂蛋白脂酶（LPL）的活性。在5、10、13和20周龄时，肥胖大鼠的脂肪垫较重，脂肪细胞较大，每个附睾脂肪垫和每个脂肪细胞的LPL均高于同窝对照组。虽然LPL每脂肪细胞增加脂肪细胞大小的增加在瘦大鼠，增加LPL活性在肥胖不能仅仅归因于脂肪细胞大小的增加。当肥胖和瘦大鼠有类似的细胞大小，LPL每个脂肪细胞仍然显着增加肥胖相比，瘦。此外，在出生后第二周，与瘦基因型（Fa/fa或Fa/Fa）相比，“前肥胖”（fa/fa）大鼠的LPL活性增加。这些数据表明，在脂肪组织中的LPL活性的早期增量的“preobese”大鼠可能显着有助于早期脂肪细胞肥大的发展过程中看到这种遗传性肥胖。此外，早期LPL活性增加可能被证明是有用的，作为一个预测肥胖症的发病。
Lipoprotein lipase (LPL) enzyme activity in epididymal adipose tissue from obese and lean Zucker rats was measured. At 5, 10, 13, and 20 wk of age obese rats have heavier fat pads, larger fat cells, and more LPL per epididymal fat pad and per fat cell than do their lean littermate controls. Although LPL per fat cell increased as fat cell size increased in lean rats, the increased LPL activity in the obese could not be attributed solely to increased fat cell size. When obese and lean rats had similar cell sizes, LPL per fat cell was still significantly increased in the obese compared to lean. Furthermore LPL activity was increased in “preobese” (fa/fa) rats compared to either lean genotype (Fa/fa or Fa/Fa) during the second postnatal week. The data suggest that early increments in LPL activity in adipose tissue of the “preobese” rat may significantly contribute to the early fat cell hypertrophy seen during the development of this genetic obesity. Furthermore, early increased LPL activity may prove useful as a predictor of the onset of obesity.